biostudies-literatureLuning Prak ETU.S. Department of Health & Human Services | NIH | National Center for Advancing Translational SciencesNCATS NIH HHSNIMH NIH HHSU.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS)NCI NIH HHSU.S. Department of Health & Human Services | National Institutes of Health (NIH)U.S. Department of Health & Human Services | NIH | National Institute of Mental HealthU.S. Department of Health & Human Services | National Institutes of Health118https://www.ebi.ac.uk/biostudies/studies/S-EPMC8948274biostudies-literatureUnknown12(1)Depression is a common and debilitating disorder in the elderly. Late-life depression (LLD) has been associated with inflammation and elevated levels of proinflammatory cytokines including interleukin (IL)-1β, tumor necrosis factor-alpha, and IL-6, but often depressed individuals have comorbid medical conditions that are associated with immune dysregulation. To determine whether depression has an association with inflammation independent of medical illness, 1120 adults were screened to identify individuals who had clinically significant depression but not medical conditions associated with systemic inflammation. In total, 66 patients with LLD screened to exclude medical conditions associated with inflammation were studied in detail along with 26 age-matched controls (HC). At baseline, circTranslational psychiatryNo increase in inflammation in late-life major depression screened to exclude physical illness.PMC8948274P30 CA016520R01 MH098260P30-CA0165205UL1TR000003R01 MH098260-02T32 MH106442UL1 TR000003Brooks TMakhoul WBeer JCSheline YIGirelli TZhao LLuning Prak ETSkarke CfalseNo increase in inflammation in late-life major depression screened to exclude physical illness.Depression is a common and debilitating disorder in the elderly. Late-life depression (LLD) has been associated with inflammation and elevated levels of proinflammatory cytokines including interleukin (IL)-1β, tumor necrosis factor-alpha, and IL-6, but often depressed individuals have comorbid medical conditions that are associated with immune dysregulation. To determine whether depression has an association with inflammation independent of medical illness, 1120 adults were screened to identify individuals who had clinically significant depression but not medical conditions associated with systemic inflammation. In total, 66 patients with LLD screened to exclude medical conditions associated with inflammation were studied in detail along with 26 age-matched controls (HC). At baseline, circ2022-01-01T00:00:00Z2022 Mar2026-05-31T07:14:14.903Z2025-04-04T07:56:08.109ZS-EPMC89482743533213410.1038/s41398-022-01883-4