{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(3)"],"submitter":["Cheng F"],"pubmed_abstract":["Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related mortality with a dismal prognosis that has changed little over the past few decades. Further understanding of the molecular pathology of PDAC progression is urgently required in order to improve the prognosis of patients with PDAC. Herein, it was observed that trefoil factor 3 (TFF3) expression was elevated in PDAC, and was positively correlated with a worse overall patient survival outcome. Forced expression of TFF3 promoted oncogenic functions of PDAC cells in vitro including cell proliferation, survival, foci formation, cancer stem cell-like behavior and invasion, ex vivo colony growth in 3D-Matrigel, and xenograft growth in vivo. Depletion or pharmacological inhibition of TFF3 inhibited these same processes. RNA"],"journal":["Cell death & disease"],"pagination":["265"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8948291"],"repository":["biostudies-literature"],"pubmed_title":["Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression."],"pmcid":["PMC8948291"],"pubmed_authors":["Basappa B","Pandey V","He C","Cheng F","Chiou YS","Guo H","Tan YQ","Lobie PE","Wang X","Zhu T"],"additional_accession":[]},"is_claimable":false,"name":"Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression.","description":"Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related mortality with a dismal prognosis that has changed little over the past few decades. Further understanding of the molecular pathology of PDAC progression is urgently required in order to improve the prognosis of patients with PDAC. Herein, it was observed that trefoil factor 3 (TFF3) expression was elevated in PDAC, and was positively correlated with a worse overall patient survival outcome. Forced expression of TFF3 promoted oncogenic functions of PDAC cells in vitro including cell proliferation, survival, foci formation, cancer stem cell-like behavior and invasion, ex vivo colony growth in 3D-Matrigel, and xenograft growth in vivo. Depletion or pharmacological inhibition of TFF3 inhibited these same processes. RNA","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-03-15T19:25:48.533Z","creation":"2025-04-06T18:10:12.197Z"},"accession":"S-EPMC8948291","cross_references":{"pubmed":["35332126"],"doi":["10.1038/s41419-022-04700-4"]}}