biostudies-literatureBocquier AITMO Cancer AVIESANe057943https://www.ebi.ac.uk/biostudies/studies/S-EPMC8948396biostudies-literatureUnknown12(3)<h4>Introduction</h4>Vaccination is an effective and safe strategy to prevent Human papillomavirus (HPV) infection and related harms. Despite various efforts by French authorities to improve HPV vaccine coverage (VC) these past few years, VC has remained far lower than in most other high-income countries. To improve it, we have coconstructed with stakeholders a school-based and primary care-based multicomponent intervention, and plan to evaluate its effectiveness, efficiency and implementation through a cluster randomised controlled trial (cRCT).<h4>Methods and analysis</h4>This pragmatic cRCT uses an incomplete factorial design to evaluate three components applied alone or in combination: (1) adolescents and parents' education and motivation at school, using eHealth tools and participatorBMJ openImpact of a school-based and primary care-based multicomponent intervention on HPV vaccination coverage among French adolescents: a cluster randomised controlled trial protocol (the PrevHPV study).PMC8948396N/AHagiu DPPartouche HOudin-Doglioni DGiraudeau BBonnay SZuo MBonmarin IRossignol LBarret ASThilly NEcollan MTron AKalecinski JSicsic JLasset CSimony MBranchereau MBocquier AVareilles GRaude JBruel SAgrinier NBotelho-Nevers EJambon GGagneux-Brunon AChevreul KGilberg SBros JPinot JPrevHPV Study groupCastagnet CGauchet APulcini CMichel MMueller JELevy-Bruhl DBel JLLe Duc-Banaszuk ASJeanleboeuf FJuneau CFall EChyderiotis SDitAsse LMfalseImpact of a school-based and primary care-based multicomponent intervention on HPV vaccination coverage among French adolescents: a cluster randomised controlled trial protocol (the PrevHPV study).<h4>Introduction</h4>Vaccination is an effective and safe strategy to prevent Human papillomavirus (HPV) infection and related harms. Despite various efforts by French authorities to improve HPV vaccine coverage (VC) these past few years, VC has remained far lower than in most other high-income countries. To improve it, we have coconstructed with stakeholders a school-based and primary care-based multicomponent intervention, and plan to evaluate its effectiveness, efficiency and implementation through a cluster randomised controlled trial (cRCT).<h4>Methods and analysis</h4>This pragmatic cRCT uses an incomplete factorial design to evaluate three components applied alone or in combination: (1) adolescents and parents' education and motivation at school, using eHealth tools and participator2022-01-01T00:00:00Z2022 Mar2026-05-09T21:52:11.464Z2025-04-04T07:35:17.098ZS-EPMC89483963533204510.1136/bmjopen-2021-057943