{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li H"],"funding":["Associazione Italiana per la Ricerca sul Cancro","Fondazione Pezcoller-SIC \"Patrizia Coser\"","University of Milan","Deutsche Forschungsgemeinschaft","The Italian Ministry of University and Scientific Research","Fondazione Italiana per la Ricerca sul Cancro","Fondazione Ricerca Molinette","Italian Ministry of Health (Ricerca Corrente; 5×1000 funds RF-2016-02361540)","Associazione Italiana Ricerca Cancro","Università degli Studi di Milano"],"pagination":["e2103249"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8948670"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(9)"],"pubmed_abstract":["Breast cancer is the most prevalent cancer and a major cause of death in women worldwide. Although early diagnosis and therapeutic intervention significantly improve patient survival rate, metastasis still accounts for most deaths. Here it is reported that, in a cohort of more than 2000 patients with breast cancer, overexpression of PI3KC2α occurs in 52% of cases and correlates with high tumor grade as well as increased probability of distant metastatic events, irrespective of the subtype. Mechanistically, it is demonstrated that PI3KC2α synthetizes a pool of PI(3,4)P2 at focal adhesions that lowers their stability and directs breast cancer cell migration, invasion, and metastasis. PI(3,4)P2 locally produced by PI3KC2α at focal adhesions recruits the Ras GTPase activating protein 3 (RASA3)"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer."],"pmcid":["PMC8948670"],"funding_grant_id":["EXC-2049 - 390688087","IG 15538","PSR2020","(20177E9EPY","EXC‐2049 – 390688087","MultiUnit-5x1000 MCO 10.000","20177E9EPY_002","IG 11904","MultiUnit‐5x1000 MCO 10.000"],"pubmed_authors":["Prever L","Martini M","Li H","Hirsch E","Hsu MY","Novelli F","Belabed H","Forni M","Nazare M","Haucke V","Pece S","De Santis MC","Porporato PE","Di Fiore PP","Zanini C","Lo WT","Gulluni F","Margaria JP"],"additional_accession":[]},"is_claimable":false,"name":"Phosphoinositide Conversion Inactivates R-RAS and Drives Metastases in Breast Cancer.","description":"Breast cancer is the most prevalent cancer and a major cause of death in women worldwide. Although early diagnosis and therapeutic intervention significantly improve patient survival rate, metastasis still accounts for most deaths. Here it is reported that, in a cohort of more than 2000 patients with breast cancer, overexpression of PI3KC2α occurs in 52% of cases and correlates with high tumor grade as well as increased probability of distant metastatic events, irrespective of the subtype. Mechanistically, it is demonstrated that PI3KC2α synthetizes a pool of PI(3,4)P2 at focal adhesions that lowers their stability and directs breast cancer cell migration, invasion, and metastasis. PI(3,4)P2 locally produced by PI3KC2α at focal adhesions recruits the Ras GTPase activating protein 3 (RASA3)","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-05T14:43:39.766Z","creation":"2025-04-05T14:43:39.766Z"},"accession":"S-EPMC8948670","cross_references":{"pubmed":["35098698"],"doi":["10.1002/advs.202103249"]}}