{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nagao K"],"funding":["Grant-in-Aid for Scientific Research","Grant-in-Aid for Scientific Research (C)"],"pagination":["3252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8948732"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(6)"],"pubmed_abstract":["p53 immunohistochemistry is considered an accurate surrogate marker reflecting the underlying TP53 mutation status and has utility in tumor diagnostics. In the present study, 269 primary CRCs were immunohistochemically evaluated for p53 expression to assess its utility in diagnostic pathology and prognostication. p53 expression was wild-type in 59 cases (23%), overexpressed in 143 cases (55%), completely lost in 50 cases (19%), and cytoplasmic in 10 cases (4%). p53 immunoreactivity was associated with tumor size (p = 0.0056), mucus production (p = 0.0015), and mismatch repair (MMR) system status (p < 0.0001). Furthermore, among CRCs with wild-type p53 expression, a significantly higher number of cases had decreased CDX2 than those with p53 overexpression (p = 0.012) or complete p53 loss (p"],"journal":["International journal of molecular sciences"],"pubmed_title":["The Complete Loss of p53 Expression Uniquely Predicts Worse Prognosis in Colorectal Cancer."],"pmcid":["PMC8948732"],"funding_grant_id":["20K07410"],"pubmed_authors":["Ueki A","Ebi M","Tsuzuki T","Nagao K","Kasugai K","Nagano A","Kasai K","Ogasawara N","Takahashi S","Inaguma S","Komura M","Koshino A","Sugimura-Nagata A"],"additional_accession":[]},"is_claimable":false,"name":"The Complete Loss of p53 Expression Uniquely Predicts Worse Prognosis in Colorectal Cancer.","description":"p53 immunohistochemistry is considered an accurate surrogate marker reflecting the underlying TP53 mutation status and has utility in tumor diagnostics. In the present study, 269 primary CRCs were immunohistochemically evaluated for p53 expression to assess its utility in diagnostic pathology and prognostication. p53 expression was wild-type in 59 cases (23%), overexpressed in 143 cases (55%), completely lost in 50 cases (19%), and cytoplasmic in 10 cases (4%). p53 immunoreactivity was associated with tumor size (p = 0.0056), mucus production (p = 0.0015), and mismatch repair (MMR) system status (p < 0.0001). Furthermore, among CRCs with wild-type p53 expression, a significantly higher number of cases had decreased CDX2 than those with p53 overexpression (p = 0.012) or complete p53 loss (p","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T18:25:55.848Z","creation":"2025-04-06T15:50:38.183Z"},"accession":"S-EPMC8948732","cross_references":{"pubmed":["35328677"],"doi":["10.3390/ijms23063252"]}}