{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim S"],"funding":["research promoting grant from the AT&C in 2020","National Research Foundation of Korea"],"pagination":["258"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8949138"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["The visceral adipose tissue (VAT) has been recognized as an endocrine organ, and VAT dysfunction could be a risk factor for Alzheimer's disease (AD). We aimed to evaluate the association of VAT metabolism with AD pathology. This cross-sectional study included 54 older subjects with cognitive impairment who underwent 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) torso positron emission tomography (PET) and 18F-florbetaben brain PET. 18F-FDG uptake in VAT on 18F-FDG PET images was used as a marker of VAT metabolism, and subjects were classified into high and low VAT metabolism groups. A voxel-based analysis revealed that the high VAT metabolism group exhibited a significantly higher cerebral amyloid-β (Aβ) burden than the low VAT metabolism group. In the volume-of-interest analysis, mul"],"journal":["Metabolites"],"pubmed_title":["Association between Visceral Adipose Tissue Metabolism and Alzheimer's Disease Pathology."],"pmcid":["PMC8949138"],"funding_grant_id":["2020R1F1A1070405","2020"],"pubmed_authors":["Kim S","Lee JS","Kim HW","Won KS","Yi HA"],"additional_accession":[]},"is_claimable":false,"name":"Association between Visceral Adipose Tissue Metabolism and Alzheimer's Disease Pathology.","description":"The visceral adipose tissue (VAT) has been recognized as an endocrine organ, and VAT dysfunction could be a risk factor for Alzheimer's disease (AD). We aimed to evaluate the association of VAT metabolism with AD pathology. This cross-sectional study included 54 older subjects with cognitive impairment who underwent 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) torso positron emission tomography (PET) and 18F-florbetaben brain PET. 18F-FDG uptake in VAT on 18F-FDG PET images was used as a marker of VAT metabolism, and subjects were classified into high and low VAT metabolism groups. A voxel-based analysis revealed that the high VAT metabolism group exhibited a significantly higher cerebral amyloid-β (Aβ) burden than the low VAT metabolism group. In the volume-of-interest analysis, mul","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T21:44:53.958Z","creation":"2025-04-19T21:44:53.958Z"},"accession":"S-EPMC8949138","cross_references":{"pubmed":["35323701"],"doi":["10.3390/metabo12030258"]}}