biostudies-literatureKim Sresearch promoting grant from the AT&C in 2020National Research Foundation of Korea258https://www.ebi.ac.uk/biostudies/studies/S-EPMC8949138biostudies-literatureUnknown12(3)The visceral adipose tissue (VAT) has been recognized as an endocrine organ, and VAT dysfunction could be a risk factor for Alzheimer's disease (AD). We aimed to evaluate the association of VAT metabolism with AD pathology. This cross-sectional study included 54 older subjects with cognitive impairment who underwent 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) torso positron emission tomography (PET) and 18F-florbetaben brain PET. 18F-FDG uptake in VAT on 18F-FDG PET images was used as a marker of VAT metabolism, and subjects were classified into high and low VAT metabolism groups. A voxel-based analysis revealed that the high VAT metabolism group exhibited a significantly higher cerebral amyloid-β (Aβ) burden than the low VAT metabolism group. In the volume-of-interest analysis, mulMetabolitesAssociation between Visceral Adipose Tissue Metabolism and Alzheimer's Disease Pathology.PMC89491382020R1F1A10704052020Kim SLee JSKim HWWon KSYi HAfalseAssociation between Visceral Adipose Tissue Metabolism and Alzheimer's Disease Pathology.The visceral adipose tissue (VAT) has been recognized as an endocrine organ, and VAT dysfunction could be a risk factor for Alzheimer's disease (AD). We aimed to evaluate the association of VAT metabolism with AD pathology. This cross-sectional study included 54 older subjects with cognitive impairment who underwent 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (18F-FDG) torso positron emission tomography (PET) and 18F-florbetaben brain PET. 18F-FDG uptake in VAT on 18F-FDG PET images was used as a marker of VAT metabolism, and subjects were classified into high and low VAT metabolism groups. A voxel-based analysis revealed that the high VAT metabolism group exhibited a significantly higher cerebral amyloid-β (Aβ) burden than the low VAT metabolism group. In the volume-of-interest analysis, mul2022-01-01T00:00:00Z2022 Mar2025-04-19T21:44:53.958Z2025-04-19T21:44:53.958ZS-EPMC89491383532370110.3390/metabo12030258