{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(3)"],"submitter":["Cremoni M"],"pubmed_abstract":["Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the beginning of the infection and the risk of subsequent progression to respiratory failure. We performed a multicentric prospective study in KT recipients with a positive RT-PCR COVID-19 test and only mild symptoms at inclusion. Blood samples were collected at baseline in a cell culture system containing T cell stimuli. We assessed T cell responsiveness by computing the ratio between the levels of Th1, Th2, Th17 and Treg cytokines produced after polyclonal stimulation and the number"],"journal":["Viruses"],"pagination":["542"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8949290"],"repository":["biostudies-literature"],"pubmed_title":["Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients."],"pmcid":["PMC8949290"],"pubmed_authors":["Demonchy E","Caillard S","Esnault V","Massa F","Glaichenhaus N","Thaunat O","Cuozzo S","Barbosa S","Sicard A","Ben Hassen N","Cremoni M","Durand M","Martinuzzi E","Le Quintrec M"],"additional_accession":[]},"is_claimable":false,"name":"Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients.","description":"Kidney transplant (KT) recipients are at increased risk of developing severe forms of COVID-19. Little is known about the immunological mechanisms underlying disease severity in these patients receiving T-cell targeting immunosuppressive drugs. We investigated the relationship between T cell responsiveness at the beginning of the infection and the risk of subsequent progression to respiratory failure. We performed a multicentric prospective study in KT recipients with a positive RT-PCR COVID-19 test and only mild symptoms at inclusion. Blood samples were collected at baseline in a cell culture system containing T cell stimuli. We assessed T cell responsiveness by computing the ratio between the levels of Th1, Th2, Th17 and Treg cytokines produced after polyclonal stimulation and the number","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T08:24:39.269Z","creation":"2024-12-04T00:55:15.981Z"},"accession":"S-EPMC8949290","cross_references":{"pubmed":["35336949"],"doi":["10.3390/v14030542"]}}