{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wilkie AR"],"funding":["National Institute of Allergy and Infectious Diseases"],"pagination":["479"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8949324"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(3)"],"pubmed_abstract":["After herpesviruses encapsidate their genomes in replication compartments (RCs) within the nuclear interior, capsids migrate to the inner nuclear membrane (INM) for nuclear egress. For human cytomegalovirus (HCMV), capsid migration depends at least in part on nuclear myosin Va. It has been reported for certain herpesviruses that the nucleoplasmic subunit of the viral nuclear egress complex (NEC) is important for this migration. To address whether this is true for HCMV, we used mass spectrometry and multiple other methods to investigate associations among the HCMV NEC nucleoplasmic subunit, UL53, myosin Va, major capsid protein, and/or capsids. We also generated complementing cells to derive and test HCMV mutants null for UL53 or the INM NEC subunit, UL50, for their importance for these ass"],"journal":["Viruses"],"pubmed_title":["Human Cytomegalovirus Nuclear Egress Complex Subunit, UL53, Associates with Capsids and Myosin Va, but Is Not Important for Capsid Localization towards the Nuclear Periphery."],"pmcid":["PMC8949324"],"funding_grant_id":["F31 AI020651","R01 AI026077"],"pubmed_authors":["Pesola JM","Coen DM","Ericsson M","Lawler JL","Fernandez R","Wilkie AR","Sharma M","Coughlin M"],"additional_accession":[]},"is_claimable":false,"name":"Human Cytomegalovirus Nuclear Egress Complex Subunit, UL53, Associates with Capsids and Myosin Va, but Is Not Important for Capsid Localization towards the Nuclear Periphery.","description":"After herpesviruses encapsidate their genomes in replication compartments (RCs) within the nuclear interior, capsids migrate to the inner nuclear membrane (INM) for nuclear egress. For human cytomegalovirus (HCMV), capsid migration depends at least in part on nuclear myosin Va. It has been reported for certain herpesviruses that the nucleoplasmic subunit of the viral nuclear egress complex (NEC) is important for this migration. To address whether this is true for HCMV, we used mass spectrometry and multiple other methods to investigate associations among the HCMV NEC nucleoplasmic subunit, UL53, myosin Va, major capsid protein, and/or capsids. We also generated complementing cells to derive and test HCMV mutants null for UL53 or the INM NEC subunit, UL50, for their importance for these ass","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-22T12:55:02.493Z","creation":"2025-04-06T00:27:12.982Z"},"accession":"S-EPMC8949324","cross_references":{"pubmed":["35336886"],"doi":["10.3390/v14030479"]}}