{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li D"],"funding":["Department of Natural Resources of Guangdong Province","National Natural Science Foundation of China"],"pagination":["158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8949366"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(3)"],"pubmed_abstract":["In this paper, eight new galaxamide analogues (Z-1~Z-8) were synthesized and evaluated for their cytotoxic activities against five cancer cell lines, MCF-7, MD-MBA-231, HepG2, Hela, and A549, using MTT assays. The modified analogue Z-6 displayed broad spectrum cytotoxic activity toward each tested cell line with IC50 values of 1.65 ± 0.30 (MCF-7), 2.91 ± 0.17 (HepG2), 4.59 ± 0.27 (MD-MBA-231), 5.69 ± 0.37 (Hela), and 5.96 ± 0.41 (A549) μg/mL, respectively. The galaxamides Z-3 and Z-6 induced concentration-dependent apoptosis of the MCF-7 cells after 72 h as evaluated by the flow cytometry experiment. The results showed that these compounds could induce MCF-7 cell apoptosis by arresting the G0/G1 phase of the cell cycle and finally achieving the effect of inhibiting the proliferation of MCF-7 cells."],"journal":["Marine drugs"],"pubmed_title":["Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents."],"pmcid":["PMC8949366"],"funding_grant_id":["GDNRC [2020] 037","2018YFC0310900","41876145, 81874292, 21672084","GDNRC [2021] 48","2019YFD0901905","202102010066, 201704030042"],"pubmed_authors":["Li D","Zhong S","Zhao B","Liao X","Xu S"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents.","description":"In this paper, eight new galaxamide analogues (Z-1~Z-8) were synthesized and evaluated for their cytotoxic activities against five cancer cell lines, MCF-7, MD-MBA-231, HepG2, Hela, and A549, using MTT assays. The modified analogue Z-6 displayed broad spectrum cytotoxic activity toward each tested cell line with IC50 values of 1.65 ± 0.30 (MCF-7), 2.91 ± 0.17 (HepG2), 4.59 ± 0.27 (MD-MBA-231), 5.69 ± 0.37 (Hela), and 5.96 ± 0.41 (A549) μg/mL, respectively. The galaxamides Z-3 and Z-6 induced concentration-dependent apoptosis of the MCF-7 cells after 72 h as evaluated by the flow cytometry experiment. The results showed that these compounds could induce MCF-7 cell apoptosis by arresting the G0/G1 phase of the cell cycle and finally achieving the effect of inhibiting the proliferation of MCF-7 cells.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-04T14:49:53.815Z","creation":"2025-04-04T14:49:53.815Z"},"accession":"S-EPMC8949366","cross_references":{"pubmed":["35323457"],"doi":["10.3390/md20030158"]}}