{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun Y"],"funding":["Hainan Yazhou Bay Seed Laboratory","National Natural Science Foundation of China","Natural Science Foundation of Hainan Province"],"pagination":["3215"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8949417"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(6)"],"pubmed_abstract":["Serotonin (5-hydroxytryptamine) plays an important role in many developmental processes and biotic/abiotic stress responses in plants. Although serotonin biosynthetic pathways in plants have been uncovered, knowledge of the mechanisms of serotonin accumulation is still limited, and no regulators have been identified to date. Here, we identified the basic leucine zipper transcription factor OsbZIP18 as a positive regulator of serotonin biosynthesis in rice. Overexpression of OsbZIP18 strongly induced the levels of serotonin and its early precursors (tryptophan and tryptamine), resulting in stunted growth and dark-brown phenotypes. A function analysis showed that OsbZIP18 activated serotonin biosynthesis genes (including tryptophan decarboxylase 1 (OsTDC1), tryptophan decarboxylase 3 (OsTDC3"],"journal":["International journal of molecular sciences"],"pubmed_title":["OsbZIP18, a Positive Regulator of Serotonin Biosynthesis, Negatively Controls the UV-B Tolerance in Rice."],"pmcid":["PMC8949417"],"funding_grant_id":["321RC476","32170267","321RC460","321MS004","B21Y10903","32001528","321RC461"],"pubmed_authors":["Wang B","Ma X","Han Y","Zhou Y","Sun Y","Yang C","Shi Y","Liu X","Niu S","Luo J","Ren J","Zhang Y","Jin C","Luo Y","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"OsbZIP18, a Positive Regulator of Serotonin Biosynthesis, Negatively Controls the UV-B Tolerance in Rice.","description":"Serotonin (5-hydroxytryptamine) plays an important role in many developmental processes and biotic/abiotic stress responses in plants. Although serotonin biosynthetic pathways in plants have been uncovered, knowledge of the mechanisms of serotonin accumulation is still limited, and no regulators have been identified to date. Here, we identified the basic leucine zipper transcription factor OsbZIP18 as a positive regulator of serotonin biosynthesis in rice. Overexpression of OsbZIP18 strongly induced the levels of serotonin and its early precursors (tryptophan and tryptamine), resulting in stunted growth and dark-brown phenotypes. A function analysis showed that OsbZIP18 activated serotonin biosynthesis genes (including tryptophan decarboxylase 1 (OsTDC1), tryptophan decarboxylase 3 (OsTDC3","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T14:50:01.899Z","creation":"2025-04-04T14:50:01.899Z"},"accession":"S-EPMC8949417","cross_references":{"pubmed":["35328636"],"doi":["10.3390/ijms23063215"]}}