{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun LL"],"funding":["the SKLDR/SIMM Project","the Natural Science Foundation of China","the National Key Research and Development Program of China","the Shanghai Rising-Star Program","\"Youth Innovation Promotion Association\" of Chinese Academy of Sciences","“Youth Innovation Promotion Association” of Chinese Academy of Sciences"],"pagination":["218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8950289"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(3)"],"pubmed_abstract":["Three complex polyoxygenated diterpenoids possessing uncommon tetradecahydro-2,13:6,9-diepoxybenzo[10]annulene scaffold, namely ximaoornatins A-C (<b>1</b>-<b>3</b>), one new eunicellin-type diterpene, litophynin K (<b>4</b>), and a related known compound, litophynol B (<b>5</b>) were isolated from the South China Sea soft coral <i>Sinularia ornata</i>. The structures and absolute configurations of <b>1</b>-<b>4</b> were established by extensive spectroscopic analysis, X-ray diffraction analysis, and/or modified Mosher's method. A plausible biosynthetic relationship of <b>1</b> and its potential precursor <b>4</b> was proposed. In a bioassay, none of the isolated compounds showed obvious anti-inflammatory activity on LPS-induced TNF-α release in RAW264.7 macrophages and PTP1B inhibitory ef"],"journal":["Marine drugs"],"pubmed_title":["Ximaoornatins A-C, Polyoxygenated Diterpenoids from the Hainan Soft Coral <i>Sinularia ornata</i>."],"pmcid":["PMC8950289"],"funding_grant_id":["No. Y202065","No. 20QA1411100","Nos. 81991521, 82022069, and 42076099","No. 2021YFF0502400","No. SIMM2103ZZ-06"],"pubmed_authors":["Sun LL","Guo YW","Li XW"],"additional_accession":[]},"is_claimable":false,"name":"Ximaoornatins A-C, Polyoxygenated Diterpenoids from the Hainan Soft Coral <i>Sinularia ornata</i>.","description":"Three complex polyoxygenated diterpenoids possessing uncommon tetradecahydro-2,13:6,9-diepoxybenzo[10]annulene scaffold, namely ximaoornatins A-C (<b>1</b>-<b>3</b>), one new eunicellin-type diterpene, litophynin K (<b>4</b>), and a related known compound, litophynol B (<b>5</b>) were isolated from the South China Sea soft coral <i>Sinularia ornata</i>. The structures and absolute configurations of <b>1</b>-<b>4</b> were established by extensive spectroscopic analysis, X-ray diffraction analysis, and/or modified Mosher's method. A plausible biosynthetic relationship of <b>1</b> and its potential precursor <b>4</b> was proposed. In a bioassay, none of the isolated compounds showed obvious anti-inflammatory activity on LPS-induced TNF-α release in RAW264.7 macrophages and PTP1B inhibitory ef","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-08-16T03:06:24.584Z","creation":"2025-04-06T13:16:31.978Z"},"accession":"S-EPMC8950289","cross_references":{"pubmed":["35323517"],"doi":["10.3390/md20030218"]}}