biostudies-literatureSun LLthe SKLDR/SIMM Projectthe Natural Science Foundation of Chinathe National Key Research and Development Program of Chinathe Shanghai Rising-Star Program"Youth Innovation Promotion Association" of Chinese Academy of Sciences“Youth Innovation Promotion Association” of Chinese Academy of Sciences218https://www.ebi.ac.uk/biostudies/studies/S-EPMC8950289biostudies-literatureUnknown20(3)Three complex polyoxygenated diterpenoids possessing uncommon tetradecahydro-2,13:6,9-diepoxybenzo[10]annulene scaffold, namely ximaoornatins A-C (<b>1</b>-<b>3</b>), one new eunicellin-type diterpene, litophynin K (<b>4</b>), and a related known compound, litophynol B (<b>5</b>) were isolated from the South China Sea soft coral <i>Sinularia ornata</i>. The structures and absolute configurations of <b>1</b>-<b>4</b> were established by extensive spectroscopic analysis, X-ray diffraction analysis, and/or modified Mosher's method. A plausible biosynthetic relationship of <b>1</b> and its potential precursor <b>4</b> was proposed. In a bioassay, none of the isolated compounds showed obvious anti-inflammatory activity on LPS-induced TNF-α release in RAW264.7 macrophages and PTP1B inhibitory efMarine drugsXimaoornatins A-C, Polyoxygenated Diterpenoids from the Hainan Soft Coral <i>Sinularia ornata</i>.PMC8950289No. Y202065No. 20QA1411100Nos. 81991521, 82022069, and 42076099No. 2021YFF0502400No. SIMM2103ZZ-06Sun LLGuo YWLi XWfalseXimaoornatins A-C, Polyoxygenated Diterpenoids from the Hainan Soft Coral <i>Sinularia ornata</i>.Three complex polyoxygenated diterpenoids possessing uncommon tetradecahydro-2,13:6,9-diepoxybenzo[10]annulene scaffold, namely ximaoornatins A-C (<b>1</b>-<b>3</b>), one new eunicellin-type diterpene, litophynin K (<b>4</b>), and a related known compound, litophynol B (<b>5</b>) were isolated from the South China Sea soft coral <i>Sinularia ornata</i>. The structures and absolute configurations of <b>1</b>-<b>4</b> were established by extensive spectroscopic analysis, X-ray diffraction analysis, and/or modified Mosher's method. A plausible biosynthetic relationship of <b>1</b> and its potential precursor <b>4</b> was proposed. In a bioassay, none of the isolated compounds showed obvious anti-inflammatory activity on LPS-induced TNF-α release in RAW264.7 macrophages and PTP1B inhibitory ef2022-01-01T00:00:00Z2022 Mar2025-08-16T03:06:24.584Z2025-04-06T13:16:31.978ZS-EPMC89502893532351710.3390/md20030218