{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shi LJ"],"funding":["NIDDK NIH HHS","National Institute of Health"],"pagination":["510"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8950324"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["Type 2 diabetes (T2D) is a major risk for atherosclerosis and its complications. <i>Apoe</i>-null (<i>Apoe</i><sup>-/-</sup>) mouse strains exhibit a wide range of variations in susceptibility to T2D and carotid atherosclerosis, with the latter being a major cause of ischemic stroke. To identify genetic connections between T2D and carotid atherosclerosis, 145 male F2 mice were generated from LP/J and BALB/cJ <i>Apoe</i><sup>-/-</sup> mice and fed 12 weeks of a Western diet. Atherosclerotic lesions in the carotid arteries, fasting, and non-fasting plasma glucose levels were measured, and genotyping was performed using miniMUGA arrays. Two significant QTL (quantitative trait loci) on chromosomes (Chr) 6 and 15 were identified for carotid lesions. The Chr15 QTL coincided precisely with QTL <i"],"journal":["Genes"],"pubmed_title":["Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice."],"pmcid":["PMC8950324"],"funding_grant_id":["R01 DK116768"],"pubmed_authors":["Chagari B","An A","Shi LJ","Chen MH","Bao Y","Shi W"],"additional_accession":[]},"is_claimable":false,"name":"Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice.","description":"Type 2 diabetes (T2D) is a major risk for atherosclerosis and its complications. <i>Apoe</i>-null (<i>Apoe</i><sup>-/-</sup>) mouse strains exhibit a wide range of variations in susceptibility to T2D and carotid atherosclerosis, with the latter being a major cause of ischemic stroke. To identify genetic connections between T2D and carotid atherosclerosis, 145 male F2 mice were generated from LP/J and BALB/cJ <i>Apoe</i><sup>-/-</sup> mice and fed 12 weeks of a Western diet. Atherosclerotic lesions in the carotid arteries, fasting, and non-fasting plasma glucose levels were measured, and genotyping was performed using miniMUGA arrays. Two significant QTL (quantitative trait loci) on chromosomes (Chr) 6 and 15 were identified for carotid lesions. The Chr15 QTL coincided precisely with QTL <i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T04:01:42.997Z","creation":"2025-04-06T10:59:34.328Z"},"accession":"S-EPMC8950324","cross_references":{"pubmed":["35328064"],"doi":["10.3390/genes13030510"]}}