biostudies-literatureShi LJNIDDK NIH HHSNational Institute of Health510https://www.ebi.ac.uk/biostudies/studies/S-EPMC8950324biostudies-literatureUnknown13(3)Type 2 diabetes (T2D) is a major risk for atherosclerosis and its complications. <i>Apoe</i>-null (<i>Apoe</i>^-/-) mouse strains exhibit a wide range of variations in susceptibility to T2D and carotid atherosclerosis, with the latter being a major cause of ischemic stroke. To identify genetic connections between T2D and carotid atherosclerosis, 145 male F2 mice were generated from LP/J and BALB/cJ <i>Apoe</i>^-/- mice and fed 12 weeks of a Western diet. Atherosclerotic lesions in the carotid arteries, fasting, and non-fasting plasma glucose levels were measured, and genotyping was performed using miniMUGA arrays. Two significant QTL (quantitative trait loci) on chromosomes (Chr) 6 and 15 were identified for carotid lesions. The Chr15 QTL coincided precisely with QTL <iGenesGenetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice.PMC8950324R01 DK116768Chagari BAn AShi LJChen MHBao YShi WfalseGenetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice.Type 2 diabetes (T2D) is a major risk for atherosclerosis and its complications. <i>Apoe</i>-null (<i>Apoe</i>^-/-) mouse strains exhibit a wide range of variations in susceptibility to T2D and carotid atherosclerosis, with the latter being a major cause of ischemic stroke. To identify genetic connections between T2D and carotid atherosclerosis, 145 male F2 mice were generated from LP/J and BALB/cJ <i>Apoe</i>^-/- mice and fed 12 weeks of a Western diet. Atherosclerotic lesions in the carotid arteries, fasting, and non-fasting plasma glucose levels were measured, and genotyping was performed using miniMUGA arrays. Two significant QTL (quantitative trait loci) on chromosomes (Chr) 6 and 15 were identified for carotid lesions. The Chr15 QTL coincided precisely with QTL <i2022-01-01T00:00:00Z2022 Mar2025-04-26T04:01:42.997Z2025-04-06T10:59:34.328ZS-EPMC89503243532806410.3390/genes13030510