biostudies-literaturePalkowski LNicolaus Copernicus University1974https://www.ebi.ac.uk/biostudies/studies/S-EPMC8953206biostudies-literatureUnknown27(6)In this study, a series of 10 novel 1-methyl-3-octyloxymethylimidazolium derivatives carrying various anionic moieties (4-hydroxybenzenesulfonate, benzenesulfonate, carvacroloxyacetate, chloride, formate, propionate, thymoloxyacetate, vanillinoxyacetate, eugenoloxyacetate and trimethylacetate) were synthesized. Compounds were tested for their antimicrobial activity against six microbe strains (Staph-ylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis, and Candida albicans), cytotoxic activity against the mouse melanoma cell line (B16 F10), and surface active properties. All synthesized compounds exhibited antimicrobial activity (expressed as minimum inhibitory concentration; in range of 0.10-27.82 mM/L), especially against Gram-positive Molecules (Basel, Switzerland)Antimicrobial and Cytotoxic Activity of Novel Imidazolium-Based Ionic Liquids.PMC895320644-IDUB 2020-1 NZ PAŁKOWSKIWojcieszak MWalkiewicz FJaroch KSkrzypczak APalkowski LMaterna KKrysinski JKarolak MBojko BPodemski JfalseAntimicrobial and Cytotoxic Activity of Novel Imidazolium-Based Ionic Liquids.In this study, a series of 10 novel 1-methyl-3-octyloxymethylimidazolium derivatives carrying various anionic moieties (4-hydroxybenzenesulfonate, benzenesulfonate, carvacroloxyacetate, chloride, formate, propionate, thymoloxyacetate, vanillinoxyacetate, eugenoloxyacetate and trimethylacetate) were synthesized. Compounds were tested for their antimicrobial activity against six microbe strains (Staph-ylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis, and Candida albicans), cytotoxic activity against the mouse melanoma cell line (B16 F10), and surface active properties. All synthesized compounds exhibited antimicrobial activity (expressed as minimum inhibitory concentration; in range of 0.10-27.82 mM/L), especially against Gram-positive 2022-01-01T00:00:00Z2022 Mar2025-04-19T13:21:00.856Z2025-04-19T13:21:00.856ZS-EPMC89532063533533510.3390/molecules27061974