biostudies-literatureUnknown27(6)Lan YHEuphormin-A (1) and euphormin-B (2), two new pyranocoumarin derivatives, and forty known compounds (3-42) were isolated from Euphorbia formosana Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for their anti-inflammatory activity. Compounds 1, 2, 10, 18, 25, and 33 significantly inhibited against superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Furthermore, compounds 25 and 33 displayed the most potent effects with IC50 values of 0.68 ± 0.18 and 1.39 ± 0.12 µM, respectively, against superoxide anion generation when compared with the positive control (2.01 ± 0.06 µM).Molecules (Basel, Switzerland)1885https://www.ebi.ac.uk/biostudies/studies/S-EPMC8954059biostudies-literatureEuphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity.PMC8954059Hwang TLLeu YLLu HHChen IHGuo TJLan YHfalseEuphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity.Euphormin-A (1) and euphormin-B (2), two new pyranocoumarin derivatives, and forty known compounds (3-42) were isolated from Euphorbia formosana Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for their anti-inflammatory activity. Compounds 1, 2, 10, 18, 25, and 33 significantly inhibited against superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Furthermore, compounds 25 and 33 displayed the most potent effects with IC50 values of 0.68 ± 0.18 and 1.39 ± 0.12 µM, respectively, against superoxide anion generation when compared with the positive control (2.01 ± 0.06 µM).2022-01-01T00:00:00Z2022 Mar2025-04-22T19:18:28.523Z2025-04-06T02:39:59.169ZS-EPMC89540593533525210.3390/molecules27061885