biostudies-literatureUnknown14(5)Lin CWThe oral cavity plays a crucial role in food digestion and immune protection. Thus, maintaining oral health is necessary. Postbiotic and heat-killed probiotic cells have shown increased antibacterial potential with stable viability compared with live strains. However, clinical evidence regarding their effect on oral health is insufficient. Therefore, in this study, we tested postbiotic lozenges of <i>Lactobacillus salivarius</i> subsp. <i>salicinius</i> AP-32, <i>L. paracasei</i> ET-66, and <i>L. plantarum</i> LPL28 and heat-killed probiotic lozenges of <i>L. salivarius</i> subsp. <i>salicinius</i> AP-32 and <i>L. paracasei</i> ET-66 for their effect on oral health. In total, 75 healthy individuals were blindly and randomly divided into placebo, postbiotic lozenge, and heat-killed probiotiAging2221-2238https://www.ebi.ac.uk/biostudies/studies/S-EPMC8954981biostudies-literatureImpact of the food grade heat-killed probiotic and postbiotic oral lozenges in oral hygiene.PMC8954981Yeh YTKuo YWLin JHLin CWHsieh PSHo HHHuang YFChen JFChen YTLiu CRLin WYHsu CHYang SFChen CWLin CHfalseImpact of the food grade heat-killed probiotic and postbiotic oral lozenges in oral hygiene.The oral cavity plays a crucial role in food digestion and immune protection. Thus, maintaining oral health is necessary. Postbiotic and heat-killed probiotic cells have shown increased antibacterial potential with stable viability compared with live strains. However, clinical evidence regarding their effect on oral health is insufficient. Therefore, in this study, we tested postbiotic lozenges of <i>Lactobacillus salivarius</i> subsp. <i>salicinius</i> AP-32, <i>L. paracasei</i> ET-66, and <i>L. plantarum</i> LPL28 and heat-killed probiotic lozenges of <i>L. salivarius</i> subsp. <i>salicinius</i> AP-32 and <i>L. paracasei</i> ET-66 for their effect on oral health. In total, 75 healthy individuals were blindly and randomly divided into placebo, postbiotic lozenge, and heat-killed probioti2022-01-01T00:00:00Z2022 Mar2026-03-15T19:14:35.537Z2025-04-04T21:33:15.053ZS-EPMC89549813523677810.18632/aging.203923