{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(6)"],"submitter":["Aati HY"],"pubmed_abstract":["A phytochemical investigation of the aerial parts of Euphorbia cactus Ehrenb. ex Boiss. revealed a new megastigmane, euphocactoside (5), along with eleven known metabolites. Euphocactoside (5) is the 3-O-glucoside derivative of a polyhydroxylated megastigmane showing unprecedented structural features. The structure of euphocactoside, including stereochemical details, was elucidated by extensive spectroscopic analysis based on 1D and 2D nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HR-ESIMS). The isolated compounds were evaluated for their cytotoxic activity against three different human cancer cell lines, namely, A549 (lung), LoVo (colon), and MCF-7 (breast), using MTT assay, and moderate to marginal activities were observed for compounds 1-3, 8 and 9 against all three cell lines."],"journal":["Plants (Basel, Switzerland)"],"pagination":["811"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8955017"],"repository":["biostudies-literature"],"pubmed_title":["Euphocactoside, a New Megastigmane Glycoside from Euphorbia cactus Growing in Saudi Arabia."],"pmcid":["PMC8955017"],"pubmed_authors":["Aati HY","Perveen S","Al-Qahtani J","Al-Taweel A","ElGamal A","Chianese G","Parvez MK","Nasr FA","Taglialatela-Scafati O","Alqahtani AS","Peng J"],"additional_accession":[]},"is_claimable":false,"name":"Euphocactoside, a New Megastigmane Glycoside from Euphorbia cactus Growing in Saudi Arabia.","description":"A phytochemical investigation of the aerial parts of Euphorbia cactus Ehrenb. ex Boiss. revealed a new megastigmane, euphocactoside (5), along with eleven known metabolites. Euphocactoside (5) is the 3-O-glucoside derivative of a polyhydroxylated megastigmane showing unprecedented structural features. The structure of euphocactoside, including stereochemical details, was elucidated by extensive spectroscopic analysis based on 1D and 2D nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HR-ESIMS). The isolated compounds were evaluated for their cytotoxic activity against three different human cancer cell lines, namely, A549 (lung), LoVo (colon), and MCF-7 (breast), using MTT assay, and moderate to marginal activities were observed for compounds 1-3, 8 and 9 against all three cell lines.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-21T23:13:20.406Z","creation":"2025-04-05T19:07:16.811Z"},"accession":"S-EPMC8955017","cross_references":{"pubmed":["35336693"],"doi":["10.3390/plants11060811"]}}