biostudies-literatureViles WDNIEHS NIH HHSNLM NIH HHSNIH HHSNIGMS NIH HHS1788-1807https://www.ebi.ac.uk/biostudies/studies/S-EPMC8955221biostudies-literatureUnknown15(4)The human gastrointestinal tract is an environment that hosts an ecosystem of microorganisms essential to human health. Vital biological processes emerge from fundamental inter- and intra-species molecular interactions that influence the assembly and composition of the gut microbiota ecology. Here we quantify the complexity of the ecological relationships within the human infant gut microbiota ecosystem as a function of the information contained in the nonlinear associations of a sequence of increasingly-specified maximum entropy representations of the system. Our paradigm frames the ecological state, in terms of the presence or absence of individual microbial ecological units that are identified by amplicon sequence variants (ASV) in the gut microenvironment, as a function of both the ecoThe annals of applied statisticsINFORMATION CONTENT OF HIGH-ORDER ASSOCIATIONS OF THE HUMAN GUT MICROBIOTA NETWORK.PMC8955221P20 GM104416P20 ES018175R01 LM012723R01 GM123014P01 ES022832UG3 OD023275K01 LM011985Li HKaragas MRViles WDMadan JCHoen AGfalseINFORMATION CONTENT OF HIGH-ORDER ASSOCIATIONS OF THE HUMAN GUT MICROBIOTA NETWORK.The human gastrointestinal tract is an environment that hosts an ecosystem of microorganisms essential to human health. Vital biological processes emerge from fundamental inter- and intra-species molecular interactions that influence the assembly and composition of the gut microbiota ecology. Here we quantify the complexity of the ecological relationships within the human infant gut microbiota ecosystem as a function of the information contained in the nonlinear associations of a sequence of increasingly-specified maximum entropy representations of the system. Our paradigm frames the ecological state, in terms of the presence or absence of individual microbial ecological units that are identified by amplicon sequence variants (ASV) in the gut microenvironment, as a function of both the eco2021-01-01T00:00:00Z2021 Dec2026-05-30T23:12:01.645Z2024-11-11T23:33:20.683ZS-EPMC89552213534249810.1214/21-aoas1449