{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zakharevich NV"],"funding":["Russian Foundation for Basic Research"],"pagination":["367"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8955288"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["The human gut microbiome is associated with various diseases, including autism spectrum disorders (ASD). Variations of the taxonomical composition in the gut microbiome of children with ASD have been observed repeatedly. However, features and parameters of the microbiome CRISPR-Cas systems in ASD have not been investigated yet. Here, we demonstrate such an analysis in order to describe the overall changes in the microbiome CRISPR-Cas systems during ASD as well as to reveal their potential to be used in diagnostics and therapy. For the systems identification, we used a combination of the publicly available tools suited for completed genomes with subsequent filtrations. In the considered data, the microbiomes of children with ASD contained fewer arrays per Gb of assembly than the control gro"],"journal":["Life (Basel, Switzerland)"],"pubmed_title":["CRISPR-Cas Systems in Gut Microbiome of Children with Autism Spectrum Disorders."],"pmcid":["PMC8955288"],"funding_grant_id":["18-29-07087"],"pubmed_authors":["Danilenko VN","Kovtun AS","Averina OV","Artamonova II","Zakharevich NV","Nikitin MS","Malov VO"],"additional_accession":[]},"is_claimable":false,"name":"CRISPR-Cas Systems in Gut Microbiome of Children with Autism Spectrum Disorders.","description":"The human gut microbiome is associated with various diseases, including autism spectrum disorders (ASD). Variations of the taxonomical composition in the gut microbiome of children with ASD have been observed repeatedly. However, features and parameters of the microbiome CRISPR-Cas systems in ASD have not been investigated yet. Here, we demonstrate such an analysis in order to describe the overall changes in the microbiome CRISPR-Cas systems during ASD as well as to reveal their potential to be used in diagnostics and therapy. For the systems identification, we used a combination of the publicly available tools suited for completed genomes with subsequent filtrations. In the considered data, the microbiomes of children with ASD contained fewer arrays per Gb of assembly than the control gro","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-04-08T17:24:46.786Z","creation":"2024-11-13T00:59:04.925Z"},"accession":"S-EPMC8955288","cross_references":{"pubmed":["35330117"],"doi":["10.3390/life12030367"]}}