{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li QR"],"funding":["Cultivating Project for Young Scholar at Hubei University of Medicine","Innovative Research Program for Graduates of Hubei University of Medicine","National Training Program of Innovation and Entrepreneurship for Undergraduates","National Natural Science Foundation of China","Hubei Provincial Natural Science Foundation","Hubei Province health and family planning scientific research project"],"pagination":["937-949"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8956315"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["The present work aims to prove the concept of tumor-targeted drug delivery mediated by platelets. Doxorubicin (DOX) attached to nanodiamonds (ND-DOX) was investigated as the model payload drug of platelets. In vitro experiments first showed that ND-DOX could be loaded in mouse platelets in a dose-dependent manner with a markedly higher efficiency and capacity than free DOX. ND-DOX-loaded platelets (Plt@ND-DOX) maintained viability and ND-DOX could be stably held in the platelets for at least 4 hr. Next, mouse Lewis lung cancer cells were found to activate Plt@ND-DOX and thereby stimulate cargo unloading of Plt@ND-DOX. The unloaded ND-DOX was taken up by co-cultured cancer cells which consequently exhibited loss of viability, proliferation suppression and apoptosis. In vivo, Plt@ND-DOX disp"],"journal":["Drug delivery"],"pubmed_title":["Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery."],"pmcid":["PMC8956315"],"funding_grant_id":["2019QDJZR02","202110929010","WJ2019Z010","2020QDJZR002","2020CFB152","YC2021016","81671818","202113249001"],"pubmed_authors":["Li LG","Li J","Wang C","Han N","Xiao RC","Li TF","Liu Y","Tang JM","Zhao L","Peng XC","Wang MF","Xu HZ","Komatsu N","Liu B","Li QR","Chen X","Yu TT","Xu YH"],"additional_accession":[]},"is_claimable":false,"name":"Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery.","description":"The present work aims to prove the concept of tumor-targeted drug delivery mediated by platelets. Doxorubicin (DOX) attached to nanodiamonds (ND-DOX) was investigated as the model payload drug of platelets. In vitro experiments first showed that ND-DOX could be loaded in mouse platelets in a dose-dependent manner with a markedly higher efficiency and capacity than free DOX. ND-DOX-loaded platelets (Plt@ND-DOX) maintained viability and ND-DOX could be stably held in the platelets for at least 4 hr. Next, mouse Lewis lung cancer cells were found to activate Plt@ND-DOX and thereby stimulate cargo unloading of Plt@ND-DOX. The unloaded ND-DOX was taken up by co-cultured cancer cells which consequently exhibited loss of viability, proliferation suppression and apoptosis. In vivo, Plt@ND-DOX disp","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T09:10:00.99Z","creation":"2025-04-04T09:10:00.99Z"},"accession":"S-EPMC8956315","cross_references":{"pubmed":["35319321"],"doi":["10.1080/10717544.2022.2053762"]}}