{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen YW"],"funding":["University of California Los Angeles","NIDDK NIH HHS","National Institutes of Health","JDRF"],"pagination":["104052"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8957031"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(4)"],"pubmed_abstract":["Drug development has been hampered by a high failure rate in clinical trials due to our incomplete understanding of drug functions across organs and species. Therefore, elucidating species- and tissue-specific drug functions can provide insights into therapeutic efficacy, potential adverse effects, and interspecies differences necessary for effective translational medicine. Here, we present PharmOmics, a drug knowledgebase and analytical tool that is hosted on an interactive web server. Using tissue- and species-specific transcriptome data from human, mouse, and rat curated from different databases, we implemented a gene-network-based approach for drug repositioning. We demonstrate the potential of PharmOmics to retrieve known therapeutic drugs and identify drugs with tissue toxicity using"],"journal":["iScience"],"pubmed_title":["PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool."],"pmcid":["PMC8957031"],"funding_grant_id":["R01 DK117850","R01 DK104363"],"pubmed_authors":["Diamante G","Yang J","Ha SM","Cohn P","Chen YW","Nghiem TX","Ding J","Blencowe M","Patel P","Yang X","Garcia J","Zaghari N","Arneson D"],"additional_accession":[]},"is_claimable":false,"name":"PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool.","description":"Drug development has been hampered by a high failure rate in clinical trials due to our incomplete understanding of drug functions across organs and species. Therefore, elucidating species- and tissue-specific drug functions can provide insights into therapeutic efficacy, potential adverse effects, and interspecies differences necessary for effective translational medicine. Here, we present PharmOmics, a drug knowledgebase and analytical tool that is hosted on an interactive web server. Using tissue- and species-specific transcriptome data from human, mouse, and rat curated from different databases, we implemented a gene-network-based approach for drug repositioning. We demonstrate the potential of PharmOmics to retrieve known therapeutic drugs and identify drugs with tissue toxicity using","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T12:56:35.028Z","creation":"2025-04-04T12:56:35.028Z"},"accession":"S-EPMC8957031","cross_references":{"pubmed":["35345455"],"doi":["10.1016/j.isci.2022.104052"]}}