{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fechtner S"],"funding":["BLRD VA","NIAID NIH HHS","National Institutes of Health","NIAMS NIH HHS","U.S. Department of Veterans Affairs","NIH HHS","NIGMS NIH HHS"],"pagination":["597-603"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8957485"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(4)"],"pubmed_abstract":["Objective
Patients with established rheumatoid arthritis (RA) demonstrate altered immune responses to Epstein-Barr virus (EBV), but the presence and roles of EBV have not been fully explored during the pre-clinical disease period. This study was undertaken to determine if EBV infection, as evidenced by an altered anti-EBV antibody response, either plays an important role in driving the development of RA or is a result of expanded RA-related autoimmunity.Methods
A total of 83 subjects with RA according to the 1987 American College of Rheumatology (ACR) criteria and 83 age-, sex-, and race-matched control subjects without RA were included in our study. We collected sera from RA subjects and matched controls during the pre-RA and post-RA diagnosis periods and tested the sera f"],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pubmed_title":["Antibody Responses to Epstein-Barr Virus in the Preclinical Period of Rheumatoid Arthritis Suggest the Presence of Increased Viral Reactivation Cycles."],"pmcid":["PMC8957485"],"funding_grant_id":["U54 GM104938","UM1 AI144292","U01‐AI‐101981","I01BX001834","R01‐AI‐24727","P30‐A‐073750","I01 BX001834","UM1‐AI‐144292","T32 AI074491","P30 AR073750","U01 AI101981","R01 AI024717","R01-AI-24727","T32‐AI‐074491"],"pubmed_authors":["Holers VM","Carlson NE","James JA","Deane KD","Johnson RL","Robinson WH","Norris JA","Berens H","Guthridge CJ","Edison JD","Demoruelle MK","Harley JB","Fechtner S","Bemis E"],"additional_accession":[]},"is_claimable":false,"name":"Antibody Responses to Epstein-Barr Virus in the Preclinical Period of Rheumatoid Arthritis Suggest the Presence of Increased Viral Reactivation Cycles.","description":"Objective
Patients with established rheumatoid arthritis (RA) demonstrate altered immune responses to Epstein-Barr virus (EBV), but the presence and roles of EBV have not been fully explored during the pre-clinical disease period. This study was undertaken to determine if EBV infection, as evidenced by an altered anti-EBV antibody response, either plays an important role in driving the development of RA or is a result of expanded RA-related autoimmunity.Methods
A total of 83 subjects with RA according to the 1987 American College of Rheumatology (ACR) criteria and 83 age-, sex-, and race-matched control subjects without RA were included in our study. We collected sera from RA subjects and matched controls during the pre-RA and post-RA diagnosis periods and tested the sera f","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-19T23:47:58.212Z","creation":"2025-04-19T23:47:58.212Z"},"accession":"S-EPMC8957485","cross_references":{"pubmed":["34605217"],"doi":["10.1002/art.41994"]}}