{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin L"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","Commonwealth Health Research Board","National Institutes of Health","NIAMS NIH HHS"],"pagination":["677-689"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8957503"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(4)"],"pubmed_abstract":["<h4>Background context</h4>Macrophages play important roles in the progression of intervertebral disc herniation and radiculopathy.<h4>Purpose</h4>To better understand the roles of macrophages in this process, we developed a new mouse model that mimics human radiculopathy.<h4>Study design/setting</h4>A preclinical randomized animal study.<h4>Methods</h4>Three types of surgeries were performed in randomly assigned Balb/c mice. These were spinal nerve exposure, traditional anterior disc puncture, and lateral disc puncture with nerve exposure (n=16/group). For the nerve exposure group, the left L5 spinal nerve was exposed without disc injury. For the traditional anterior puncture, L5/6 disc was punctured by an anterior approach as previously established. For lateral puncture with nerve exposu"],"journal":["The spine journal : official journal of the North American Spine Society"],"pubmed_title":["Heterogeneous macrophages contribute to the pathology of disc herniation induced radiculopathy."],"pmcid":["PMC8957503"],"funding_grant_id":["R21 AR078547","AR064792","AR072334","R21 AR072334","R01 AR064792","AR078547","R01 AR078888"],"pubmed_authors":["Xiao L","Sung SJ","Balian G","Li XJ","Pan A","Jin L","Ding M"],"additional_accession":[]},"is_claimable":false,"name":"Heterogeneous macrophages contribute to the pathology of disc herniation induced radiculopathy.","description":"<h4>Background context</h4>Macrophages play important roles in the progression of intervertebral disc herniation and radiculopathy.<h4>Purpose</h4>To better understand the roles of macrophages in this process, we developed a new mouse model that mimics human radiculopathy.<h4>Study design/setting</h4>A preclinical randomized animal study.<h4>Methods</h4>Three types of surgeries were performed in randomly assigned Balb/c mice. These were spinal nerve exposure, traditional anterior disc puncture, and lateral disc puncture with nerve exposure (n=16/group). For the nerve exposure group, the left L5 spinal nerve was exposed without disc injury. For the traditional anterior puncture, L5/6 disc was punctured by an anterior approach as previously established. For lateral puncture with nerve exposu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-19T23:47:45.878Z","creation":"2025-04-19T23:47:45.878Z"},"accession":"S-EPMC8957503","cross_references":{"pubmed":["34718176"],"doi":["10.1016/j.spinee.2021.10.014"]}}