biostudies-literatureJin LNational Institute of Arthritis and Musculoskeletal and Skin DiseasesCommonwealth Health Research BoardNational Institutes of HealthNIAMS NIH HHS677-689https://www.ebi.ac.uk/biostudies/studies/S-EPMC8957503biostudies-literatureUnknown22(4)<h4>Background context</h4>Macrophages play important roles in the progression of intervertebral disc herniation and radiculopathy.<h4>Purpose</h4>To better understand the roles of macrophages in this process, we developed a new mouse model that mimics human radiculopathy.<h4>Study design/setting</h4>A preclinical randomized animal study.<h4>Methods</h4>Three types of surgeries were performed in randomly assigned Balb/c mice. These were spinal nerve exposure, traditional anterior disc puncture, and lateral disc puncture with nerve exposure (n=16/group). For the nerve exposure group, the left L5 spinal nerve was exposed without disc injury. For the traditional anterior puncture, L5/6 disc was punctured by an anterior approach as previously established. For lateral puncture with nerve exposuThe spine journal : official journal of the North American Spine SocietyHeterogeneous macrophages contribute to the pathology of disc herniation induced radiculopathy.PMC8957503R21 AR078547AR064792AR072334R21 AR072334R01 AR064792AR078547R01 AR078888Xiao LSung SJBalian GLi XJPan AJin LDing MfalseHeterogeneous macrophages contribute to the pathology of disc herniation induced radiculopathy.<h4>Background context</h4>Macrophages play important roles in the progression of intervertebral disc herniation and radiculopathy.<h4>Purpose</h4>To better understand the roles of macrophages in this process, we developed a new mouse model that mimics human radiculopathy.<h4>Study design/setting</h4>A preclinical randomized animal study.<h4>Methods</h4>Three types of surgeries were performed in randomly assigned Balb/c mice. These were spinal nerve exposure, traditional anterior disc puncture, and lateral disc puncture with nerve exposure (n=16/group). For the nerve exposure group, the left L5 spinal nerve was exposed without disc injury. For the traditional anterior puncture, L5/6 disc was punctured by an anterior approach as previously established. For lateral puncture with nerve exposu2022-01-01T00:00:00Z2022 Apr2025-04-19T23:47:45.878Z2025-04-19T23:47:45.878ZS-EPMC89575033471817610.1016/j.spinee.2021.10.014