{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fletcher P"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["677-694"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8957518"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["45(2)"],"pubmed_abstract":["Acute and chronic inflammation are vital contributing factors to pulmonary diseases which can be triggered by exposure to occupational and man-made particles; however, there are no established treatments. One potential treatment shown to have anti-inflammatory capabilities is the dietary supplement docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid found in fish oil. DHA's anti-inflammatory mechanisms are unclear for particle-induced inflammation; therefore, this study evaluated DHA as a prophylactic treatment for semi-acute and chronic particle-induced inflammation in vivo. Balb/c mice were fed a control or 1% DHA diet and exposed to dispersion media, an inflammatory multi-walled carbon nanotube (MWCNT), or crystalline silica (SiO<sub>2</sub>) either once (semi-acute) or on"],"journal":["Inflammation"],"pubmed_title":["Dietary Docosahexaenoic Acid as a Potential Treatment for Semi-acute and Chronic Particle-Induced Pulmonary Inflammation in Balb/c Mice."],"pmcid":["PMC8957518"],"funding_grant_id":["R01 ES023209","R01 ES027353","F31 ES028100","P30 GM103338"],"pubmed_authors":["Fletcher P","Rhoderick JF","Postma B","Holian A","Pestka JJ","Buford M","Hamilton RF"],"additional_accession":[]},"is_claimable":false,"name":"Dietary Docosahexaenoic Acid as a Potential Treatment for Semi-acute and Chronic Particle-Induced Pulmonary Inflammation in Balb/c Mice.","description":"Acute and chronic inflammation are vital contributing factors to pulmonary diseases which can be triggered by exposure to occupational and man-made particles; however, there are no established treatments. One potential treatment shown to have anti-inflammatory capabilities is the dietary supplement docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid found in fish oil. DHA's anti-inflammatory mechanisms are unclear for particle-induced inflammation; therefore, this study evaluated DHA as a prophylactic treatment for semi-acute and chronic particle-induced inflammation in vivo. Balb/c mice were fed a control or 1% DHA diet and exposed to dispersion media, an inflammatory multi-walled carbon nanotube (MWCNT), or crystalline silica (SiO<sub>2</sub>) either once (semi-acute) or on","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-19T23:46:18.721Z","creation":"2025-04-19T23:46:18.721Z"},"accession":"S-EPMC8957518","cross_references":{"pubmed":["34655011"],"doi":["10.1007/s10753-021-01576-y"]}}