biostudies-literatureFletcher PNational Institute of Environmental Health SciencesNIEHS NIH HHSNational Institute of General Medical SciencesNIGMS NIH HHS677-694https://www.ebi.ac.uk/biostudies/studies/S-EPMC8957518biostudies-literatureUnknown45(2)Acute and chronic inflammation are vital contributing factors to pulmonary diseases which can be triggered by exposure to occupational and man-made particles; however, there are no established treatments. One potential treatment shown to have anti-inflammatory capabilities is the dietary supplement docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid found in fish oil. DHA's anti-inflammatory mechanisms are unclear for particle-induced inflammation; therefore, this study evaluated DHA as a prophylactic treatment for semi-acute and chronic particle-induced inflammation in vivo. Balb/c mice were fed a control or 1% DHA diet and exposed to dispersion media, an inflammatory multi-walled carbon nanotube (MWCNT), or crystalline silica (SiO₂) either once (semi-acute) or onInflammationDietary Docosahexaenoic Acid as a Potential Treatment for Semi-acute and Chronic Particle-Induced Pulmonary Inflammation in Balb/c Mice.PMC8957518R01 ES023209R01 ES027353F31 ES028100P30 GM103338Fletcher PRhoderick JFPostma BHolian APestka JJBuford MHamilton RFfalseDietary Docosahexaenoic Acid as a Potential Treatment for Semi-acute and Chronic Particle-Induced Pulmonary Inflammation in Balb/c Mice.Acute and chronic inflammation are vital contributing factors to pulmonary diseases which can be triggered by exposure to occupational and man-made particles; however, there are no established treatments. One potential treatment shown to have anti-inflammatory capabilities is the dietary supplement docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid found in fish oil. DHA's anti-inflammatory mechanisms are unclear for particle-induced inflammation; therefore, this study evaluated DHA as a prophylactic treatment for semi-acute and chronic particle-induced inflammation in vivo. Balb/c mice were fed a control or 1% DHA diet and exposed to dispersion media, an inflammatory multi-walled carbon nanotube (MWCNT), or crystalline silica (SiO₂) either once (semi-acute) or on2022-01-01T00:00:00Z2022 Apr2025-04-19T23:46:18.721Z2025-04-19T23:46:18.721ZS-EPMC89575183465501110.1007/s10753-021-01576-y