biostudies-literatureBoyer ALNational Center for Advancing Translational SciencesNCATS NIH HHSDivision of Cancer Prevention, National Cancer InstituteNCI NIH HHS816-819https://www.ebi.ac.uk/biostudies/studies/S-EPMC8957580biostudies-literatureUnknown74(3)Chronically elevated levels of inflammatory biomarkers may contribute to the development of cancer and diet may be an important factor in the interplay between inflammation and cancer. We examined associations between glycemic load (GL), glycemic index (GI), and adapted dietary inflammatory index (ADII) and markers of inflammation and adipokines in 135 premenopausal women at high genetic risk for breast cancer (NCT00892515). We assessed body mass index (BMI), 3-day food records, and blood biomarkers TNF-<i>α</i>, IL-12, CCL2, IL-10, leptin, and adiponectin. Regression models assessed associations between dietary variables and biomarkers, adjusted for caloric intake and BMI. Participants were on average 34.2 years old with mean BMI of 26.8 kg/m². Significantly higher levels of ILNutrition and cancerAssociation of Inflammatory Diets with Inflammatory Biomarkers in Women at High Genetic Risk for Breast Cancer.PMC8957580KL2 TR002015R01CA131333R01 CA131333UL1 TR000003UL1 TR002014KL2TR002015, UL1 TR000003, UL1TR002014Arikawa AYSturgeon KMSchmitz KHBoyer ALfalseAssociation of Inflammatory Diets with Inflammatory Biomarkers in Women at High Genetic Risk for Breast Cancer.Chronically elevated levels of inflammatory biomarkers may contribute to the development of cancer and diet may be an important factor in the interplay between inflammation and cancer. We examined associations between glycemic load (GL), glycemic index (GI), and adapted dietary inflammatory index (ADII) and markers of inflammation and adipokines in 135 premenopausal women at high genetic risk for breast cancer (NCT00892515). We assessed body mass index (BMI), 3-day food records, and blood biomarkers TNF-<i>α</i>, IL-12, CCL2, IL-10, leptin, and adiponectin. Regression models assessed associations between dietary variables and biomarkers, adjusted for caloric intake and BMI. Participants were on average 34.2 years old with mean BMI of 26.8 kg/m². Significantly higher levels of IL2022-01-01T00:00:00Z20222025-04-22T10:09:36.259Z2025-04-05T23:30:02.775ZS-EPMC89575803461542910.1080/01635581.2021.1986554