{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Yang YJ"],"funding":["National Cheng Kung University Hospital"],"pubmed_abstract":["<i>Helicobacter pylori</i> causes gastrointestinal diseases, the manifestations of diseases are more serious in adults than in children. Lewis antigen expressions on the gastric epithelium serves as receptors targeted by <i>H. pylori</i>. Moreover, the MAPK signaling pathway involves glycoprotein synthesis of Lewis antigens. We aimed to investigate whether differences in <i>H. pylori</i>-induced MAPK responses mediate gastric Lewis antigens expression and colonization density differently in children and adults. We used human stomach fetal epithelium (HSFE) and SV40-immortalized human normal gastric epithelial (GES-1) cell lines to mimic primary gastric epithelium of children and adults, respectively. <i>H. pylori</i> colonization intensity and Lewis antigens were significantly higher in GE"],"journal":["Frontiers in immunology"],"pagination":["849512"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8957798"],"repository":["biostudies-literature"],"pubmed_title":["Differential <i>H. pylori</i>-Induced MAPK Responses Regulate Lewis Antigen Expression and Colonization Density on Gastric Epithelial Cells Between Children and Adults."],"pmcid":["PMC8957798"],"pubmed_authors":["Lu CL","Yang YJ","Sheu BS"],"additional_accession":[]},"is_claimable":false,"name":"Differential <i>H. pylori</i>-Induced MAPK Responses Regulate Lewis Antigen Expression and Colonization Density on Gastric Epithelial Cells Between Children and Adults.","description":"<i>Helicobacter pylori</i> causes gastrointestinal diseases, the manifestations of diseases are more serious in adults than in children. Lewis antigen expressions on the gastric epithelium serves as receptors targeted by <i>H. pylori</i>. Moreover, the MAPK signaling pathway involves glycoprotein synthesis of Lewis antigens. We aimed to investigate whether differences in <i>H. pylori</i>-induced MAPK responses mediate gastric Lewis antigens expression and colonization density differently in children and adults. We used human stomach fetal epithelium (HSFE) and SV40-immortalized human normal gastric epithelial (GES-1) cell lines to mimic primary gastric epithelium of children and adults, respectively. <i>H. pylori</i> colonization intensity and Lewis antigens were significantly higher in GE","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-14T14:50:42.54Z","creation":"2025-05-31T22:23:48.643Z"},"accession":"S-EPMC8957798","cross_references":{"pubmed":["35350782"],"doi":["10.3389/fimmu.2022.849512"]}}