biostudies-literatureUnknown13Yang YJNational Cheng Kung University Hospital<i>Helicobacter pylori</i> causes gastrointestinal diseases, the manifestations of diseases are more serious in adults than in children. Lewis antigen expressions on the gastric epithelium serves as receptors targeted by <i>H. pylori</i>. Moreover, the MAPK signaling pathway involves glycoprotein synthesis of Lewis antigens. We aimed to investigate whether differences in <i>H. pylori</i>-induced MAPK responses mediate gastric Lewis antigens expression and colonization density differently in children and adults. We used human stomach fetal epithelium (HSFE) and SV40-immortalized human normal gastric epithelial (GES-1) cell lines to mimic primary gastric epithelium of children and adults, respectively. <i>H. pylori</i> colonization intensity and Lewis antigens were significantly higher in GEFrontiers in immunology849512https://www.ebi.ac.uk/biostudies/studies/S-EPMC8957798biostudies-literatureDifferential <i>H. pylori</i>-Induced MAPK Responses Regulate Lewis Antigen Expression and Colonization Density on Gastric Epithelial Cells Between Children and Adults.PMC8957798Lu CLYang YJSheu BSfalseDifferential <i>H. pylori</i>-Induced MAPK Responses Regulate Lewis Antigen Expression and Colonization Density on Gastric Epithelial Cells Between Children and Adults.<i>Helicobacter pylori</i> causes gastrointestinal diseases, the manifestations of diseases are more serious in adults than in children. Lewis antigen expressions on the gastric epithelium serves as receptors targeted by <i>H. pylori</i>. Moreover, the MAPK signaling pathway involves glycoprotein synthesis of Lewis antigens. We aimed to investigate whether differences in <i>H. pylori</i>-induced MAPK responses mediate gastric Lewis antigens expression and colonization density differently in children and adults. We used human stomach fetal epithelium (HSFE) and SV40-immortalized human normal gastric epithelial (GES-1) cell lines to mimic primary gastric epithelium of children and adults, respectively. <i>H. pylori</i> colonization intensity and Lewis antigens were significantly higher in GE2022-01-01T00:00:00Z20222026-07-14T14:50:42.54Z2025-05-31T22:23:48.643ZS-EPMC89577983535078210.3389/fimmu.2022.849512