{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Hakibilen C"],"pubmed_abstract":["Cellular adhesion and migration are key functions that are disrupted in numerous diseases. We report that desmin, a type-III muscle-specific intermediate filament, is a novel cell adhesion regulator. Expression of p.R406W mutant desmin, identified in patients with desmin-related myopathy, modified focal adhesion area and expression of adhesion-signaling genes in myogenic C2C12 cells. Satellite cells extracted from desmin-knock-out (DesKO) and desmin-knock-in-p.R405W (DesKI-R405W) mice were less adhesive and migrated faster than those from wild-type mice. Moreover, we observed mislocalized and aggregated vinculin, a key component of cell adhesion, in DesKO and DesKI-R405W muscles. Vinculin expression was also increased in desmin-related myopathy patient muscles. Together, our results establ"],"journal":["Frontiers in cell and developmental biology"],"pagination":["783724"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8957967"],"repository":["biostudies-literature"],"pubmed_title":["Desmin Modulates Muscle Cell Adhesion and Migration."],"pmcid":["PMC8957967"],"pubmed_authors":["Bourgois-Rocha F","Cabet E","Daher MT","Tian C","Agbulut O","Joanne P","Vicart P","Delort F","Rivas E","Batonnet-Pichon S","Cardoso O","Hakibilen C","Ferreiro A","Madruga M","Lilienbaum A","Henon S"],"additional_accession":[]},"is_claimable":false,"name":"Desmin Modulates Muscle Cell Adhesion and Migration.","description":"Cellular adhesion and migration are key functions that are disrupted in numerous diseases. We report that desmin, a type-III muscle-specific intermediate filament, is a novel cell adhesion regulator. Expression of p.R406W mutant desmin, identified in patients with desmin-related myopathy, modified focal adhesion area and expression of adhesion-signaling genes in myogenic C2C12 cells. Satellite cells extracted from desmin-knock-out (DesKO) and desmin-knock-in-p.R405W (DesKI-R405W) mice were less adhesive and migrated faster than those from wild-type mice. Moreover, we observed mislocalized and aggregated vinculin, a key component of cell adhesion, in DesKO and DesKI-R405W muscles. Vinculin expression was also increased in desmin-related myopathy patient muscles. Together, our results establ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T15:06:55.678Z","creation":"2025-04-07T01:42:26.263Z"},"accession":"S-EPMC8957967","cross_references":{"pubmed":["35350386"],"doi":["10.3389/fcell.2022.783724"]}}