biostudies-literatureUnknown12Zeng L<h4>Background</h4>Gastric cancer (GC) is one of the most common cancer types, especially in Asian countries. Hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to improve the progression-free survival among gastric cancer patients with peritoneal metastases; however, not all patients demonstrate response to HIPEC.<h4>Methods</h4>Biomarkers are needed to select patients for effective treatment of HIPEC. Here, we performed whole-exome sequencing on tumor samples from 18 gastric cancer patients who received HIPEC treatment and assessed the association between genomic mutation features and progression-free survival. Exome sequencing was further conducted on tumor samples from additional 15 gastric cancer patients as a replication study.<h4>Results</h4>The tumor mutational burdenFrontiers in oncology796263https://www.ebi.ac.uk/biostudies/studies/S-EPMC8958003biostudies-literatureTumor Mutational Burden Associated With Response to Hyperthermic Intraperitoneal Chemotherapy.PMC8958003Liu HLiu KLi JHuang JZeng LCui WXia QGuan TCui STang HWen JLei ZShao YLuo JHuang XTian YLiao QfalseTumor Mutational Burden Associated With Response to Hyperthermic Intraperitoneal Chemotherapy.<h4>Background</h4>Gastric cancer (GC) is one of the most common cancer types, especially in Asian countries. Hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to improve the progression-free survival among gastric cancer patients with peritoneal metastases; however, not all patients demonstrate response to HIPEC.<h4>Methods</h4>Biomarkers are needed to select patients for effective treatment of HIPEC. Here, we performed whole-exome sequencing on tumor samples from 18 gastric cancer patients who received HIPEC treatment and assessed the association between genomic mutation features and progression-free survival. Exome sequencing was further conducted on tumor samples from additional 15 gastric cancer patients as a replication study.<h4>Results</h4>The tumor mutational burden2022-01-01T00:00:00Z20222025-04-22T18:21:33.63Z2025-04-06T02:23:54.648ZS-EPMC89580033535056210.3389/fonc.2022.796263