{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2021"],"submitter":["Zhou J"],"pubmed_abstract":["In the current study, a Cu(II) coordination polymer (CP) has been created in success with the solvothermal reaction between an asymmetrical rigid N-heterocyclic carboxylatic acid (HL) and Cu(NO<sub>3</sub>)<sub>2</sub>·3H<sub>2</sub>O in the existence of 1,3-H<sub>2</sub>bdc, the second assistant ligand (in which 1,3-H<sub>2</sub>bdc is benzene-1,3-dicarboxylic acid and HL is 1-(4-carboxylphenyl)-3-(prazin-2-yl)-1H-1,2,4-triazole), and the chemical composition of this compound is [Cu<sub>2</sub>(L)<sub>2</sub>(1,3-bdc)(H<sub>2</sub>O)<sub>2</sub>]n (<b>1</b>). In the biological aspect, we screened the antiproliferation activity of the Cu(II) coordination polymer on five kinds of human cancer cell lines. IC<sub>50</sub> and MTT assay results indicated that complex <b>1</b> had a spectral an"],"journal":["Disease markers"],"pagination":["2174290"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8958075"],"repository":["biostudies-literature"],"pubmed_title":["Cu(II) Coordination Polymer Inhibits Liver Cancer Development via Targeting BCL-2 Protein and Activating Apoptotic Pathway."],"pmcid":["PMC8958075"],"pubmed_authors":["Peng X","Li X","Kong X","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Cu(II) Coordination Polymer Inhibits Liver Cancer Development via Targeting BCL-2 Protein and Activating Apoptotic Pathway.","description":"In the current study, a Cu(II) coordination polymer (CP) has been created in success with the solvothermal reaction between an asymmetrical rigid N-heterocyclic carboxylatic acid (HL) and Cu(NO<sub>3</sub>)<sub>2</sub>·3H<sub>2</sub>O in the existence of 1,3-H<sub>2</sub>bdc, the second assistant ligand (in which 1,3-H<sub>2</sub>bdc is benzene-1,3-dicarboxylic acid and HL is 1-(4-carboxylphenyl)-3-(prazin-2-yl)-1H-1,2,4-triazole), and the chemical composition of this compound is [Cu<sub>2</sub>(L)<sub>2</sub>(1,3-bdc)(H<sub>2</sub>O)<sub>2</sub>]n (<b>1</b>). In the biological aspect, we screened the antiproliferation activity of the Cu(II) coordination polymer on five kinds of human cancer cell lines. IC<sub>50</sub> and MTT assay results indicated that complex <b>1</b> had a spectral an","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-05T00:27:20.79Z","creation":"2025-04-05T00:27:20.79Z"},"accession":"S-EPMC8958075","cross_references":{"pubmed":["35356669"],"doi":["10.1155/2021/2174290"]}}