biostudies-literatureUnknown2021Zhou JIn the current study, a Cu(II) coordination polymer (CP) has been created in success with the solvothermal reaction between an asymmetrical rigid N-heterocyclic carboxylatic acid (HL) and Cu(NO₃)₂·3H₂O in the existence of 1,3-H₂bdc, the second assistant ligand (in which 1,3-H₂bdc is benzene-1,3-dicarboxylic acid and HL is 1-(4-carboxylphenyl)-3-(prazin-2-yl)-1H-1,2,4-triazole), and the chemical composition of this compound is [Cu₂(L)₂(1,3-bdc)(H₂O)₂]n (<b>1</b>). In the biological aspect, we screened the antiproliferation activity of the Cu(II) coordination polymer on five kinds of human cancer cell lines. IC₅₀ and MTT assay results indicated that complex <b>1</b> had a spectral anDisease markers2174290https://www.ebi.ac.uk/biostudies/studies/S-EPMC8958075biostudies-literatureCu(II) Coordination Polymer Inhibits Liver Cancer Development via Targeting BCL-2 Protein and Activating Apoptotic Pathway.PMC8958075Peng XLi XKong XZhou JfalseCu(II) Coordination Polymer Inhibits Liver Cancer Development via Targeting BCL-2 Protein and Activating Apoptotic Pathway.In the current study, a Cu(II) coordination polymer (CP) has been created in success with the solvothermal reaction between an asymmetrical rigid N-heterocyclic carboxylatic acid (HL) and Cu(NO₃)₂·3H₂O in the existence of 1,3-H₂bdc, the second assistant ligand (in which 1,3-H₂bdc is benzene-1,3-dicarboxylic acid and HL is 1-(4-carboxylphenyl)-3-(prazin-2-yl)-1H-1,2,4-triazole), and the chemical composition of this compound is [Cu₂(L)₂(1,3-bdc)(H₂O)₂]n (<b>1</b>). In the biological aspect, we screened the antiproliferation activity of the Cu(II) coordination polymer on five kinds of human cancer cell lines. IC₅₀ and MTT assay results indicated that complex <b>1</b> had a spectral an2021-01-01T00:00:00Z20212025-04-05T00:27:20.79Z2025-04-05T00:27:20.79ZS-EPMC89580753535666910.1155/2021/2174290