{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang X"],"funding":["Hulunbuir City Science and Technology Bureau Scientific Research Program Project"],"pagination":["2054876"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8958104"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["Both rs1801133 mutation on Methylenetetrahydrofolate reductase (MTHFR) gene and transcription factor peroxisome proliferator-activated gamma (PPARG) have been associated with plasma homocysteine (Hcy) levels and hypertension. However, their role in H-type hypertension remains unclear. In this study, we first tested the association between rs1801133 genotypes and Hcy level in H-type hypertension using clinical profiles collected from 203 patients before and after the treatment using enalapril maleate and folic acid tablets (EMFAT). Then, we constructed a literature-based pathway analysis to explore the role of the rs1801133-PPARG signaling pathway in H-type hypertension and its treatment. Although presented similar blood pressure, the patients with TT genotype of rs1801133 were much younger"],"journal":["PPAR research"],"pubmed_title":["Explore the Role of the rs1801133-PPARG Pathway in the H-type Hypertension."],"pmcid":["PMC8958104"],"funding_grant_id":["2018NS021"],"pubmed_authors":["Liu Y","He T","Liang X","Zhang Y","Gao L","Rong D","Wei L"],"additional_accession":[]},"is_claimable":false,"name":"Explore the Role of the rs1801133-PPARG Pathway in the H-type Hypertension.","description":"Both rs1801133 mutation on Methylenetetrahydrofolate reductase (MTHFR) gene and transcription factor peroxisome proliferator-activated gamma (PPARG) have been associated with plasma homocysteine (Hcy) levels and hypertension. However, their role in H-type hypertension remains unclear. In this study, we first tested the association between rs1801133 genotypes and Hcy level in H-type hypertension using clinical profiles collected from 203 patients before and after the treatment using enalapril maleate and folic acid tablets (EMFAT). Then, we constructed a literature-based pathway analysis to explore the role of the rs1801133-PPARG signaling pathway in H-type hypertension and its treatment. Although presented similar blood pressure, the patients with TT genotype of rs1801133 were much younger","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T10:46:51.698Z","creation":"2024-10-19T09:16:56.809Z"},"accession":"S-EPMC8958104","cross_references":{"pubmed":["35356087"],"doi":["10.1155/2022/2054876"]}}