biostudies-literatureLiang XHulunbuir City Science and Technology Bureau Scientific Research Program Project2054876https://www.ebi.ac.uk/biostudies/studies/S-EPMC8958104biostudies-literatureUnknown2022Both rs1801133 mutation on Methylenetetrahydrofolate reductase (MTHFR) gene and transcription factor peroxisome proliferator-activated gamma (PPARG) have been associated with plasma homocysteine (Hcy) levels and hypertension. However, their role in H-type hypertension remains unclear. In this study, we first tested the association between rs1801133 genotypes and Hcy level in H-type hypertension using clinical profiles collected from 203 patients before and after the treatment using enalapril maleate and folic acid tablets (EMFAT). Then, we constructed a literature-based pathway analysis to explore the role of the rs1801133-PPARG signaling pathway in H-type hypertension and its treatment. Although presented similar blood pressure, the patients with TT genotype of rs1801133 were much youngerPPAR researchExplore the Role of the rs1801133-PPARG Pathway in the H-type Hypertension.PMC89581042018NS021Liu YHe TLiang XZhang YGao LRong DWei LfalseExplore the Role of the rs1801133-PPARG Pathway in the H-type Hypertension.Both rs1801133 mutation on Methylenetetrahydrofolate reductase (MTHFR) gene and transcription factor peroxisome proliferator-activated gamma (PPARG) have been associated with plasma homocysteine (Hcy) levels and hypertension. However, their role in H-type hypertension remains unclear. In this study, we first tested the association between rs1801133 genotypes and Hcy level in H-type hypertension using clinical profiles collected from 203 patients before and after the treatment using enalapril maleate and folic acid tablets (EMFAT). Then, we constructed a literature-based pathway analysis to explore the role of the rs1801133-PPARG signaling pathway in H-type hypertension and its treatment. Although presented similar blood pressure, the patients with TT genotype of rs1801133 were much younger2022-01-01T00:00:00Z20222025-04-19T10:46:51.698Z2024-10-19T09:16:56.809ZS-EPMC89581043535608710.1155/2022/2054876