{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Oloo WN"],"funding":["Orsz??gos Tudom??nyos Kutat??si Alapprogramok","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["37-41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8958355"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(1)"],"pubmed_abstract":["Herein are described substrate oxidations with H<sub>2</sub>O<sub>2</sub> catalyzed by [Fe<sup>II</sup>(IndH)(CH<sub>3</sub>CN)<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub> [IndH = 1,3-bis(2'-pyridylimino)isoindoline], involving a spectroscopically characterized (μ-oxo)(μ-1,2-peroxo)diiron(III) intermediate (<b>2</b>) that is capable of olefin epoxidation and alkane hydroxylation including cyclohexane. Species <b>2</b> also converts ketones to lactones with a decay rate dependent on [ketone], suggesting direct nucleophilic attack of the substrate carbonyl group by the peroxo species. In contrast, peroxo decay is unaffected by the addition of olefins or alkanes, but the label from H<sub>2</sub><sup>18</sup>O is incorporated into the the epoxide and alcohol products, implicating a high-valent iron-oxo oxidant that derives from O-O bond cleavage of the peroxo intermediate. These results demonstrate an ambiphilic diferric-peroxo intermediate that mimics the range of oxidative reactivities associated with O<sub>2</sub>-activating nonheme diiron enzymes."],"journal":["Inorganic chemistry"],"pubmed_title":["Nonheme Diiron Oxygenase Mimic That Generates a Diferric-Peroxo Intermediate Capable of Catalytic Olefin Epoxidation and Alkane Hydroxylation Including Cyclohexane."],"pmcid":["PMC8958355"],"funding_grant_id":["TKP2020-IKA-07","R01 GM-38767","R35 GM131721","GINOP-2.3.2-15-2016-00049","R35 GM-131721","K108489","R01 GM038767"],"pubmed_authors":["Que L","Kaizer J","Szavuly M","Oloo WN"],"additional_accession":[]},"is_claimable":false,"name":"Nonheme Diiron Oxygenase Mimic That Generates a Diferric-Peroxo Intermediate Capable of Catalytic Olefin Epoxidation and Alkane Hydroxylation Including Cyclohexane.","description":"Herein are described substrate oxidations with H<sub>2</sub>O<sub>2</sub> catalyzed by [Fe<sup>II</sup>(IndH)(CH<sub>3</sub>CN)<sub>3</sub>](ClO<sub>4</sub>)<sub>2</sub> [IndH = 1,3-bis(2'-pyridylimino)isoindoline], involving a spectroscopically characterized (μ-oxo)(μ-1,2-peroxo)diiron(III) intermediate (<b>2</b>) that is capable of olefin epoxidation and alkane hydroxylation including cyclohexane. Species <b>2</b> also converts ketones to lactones with a decay rate dependent on [ketone], suggesting direct nucleophilic attack of the substrate carbonyl group by the peroxo species. In contrast, peroxo decay is unaffected by the addition of olefins or alkanes, but the label from H<sub>2</sub><sup>18</sup>O is incorporated into the the epoxide and alcohol products, implicating a high-valent iron-oxo oxidant that derives from O-O bond cleavage of the peroxo intermediate. These results demonstrate an ambiphilic diferric-peroxo intermediate that mimics the range of oxidative reactivities associated with O<sub>2</sub>-activating nonheme diiron enzymes.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-05T22:19:02.266Z","creation":"2025-04-05T22:19:02.266Z"},"accession":"S-EPMC8958355","cross_references":{"pubmed":["34894683"],"doi":["10.1021/acs.inorgchem.1c03468"]}}