{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li H"],"funding":["NIDCR NIH HHS","NIAID NIH HHS","National Institutes of Health"],"pagination":["3303-3313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8958665"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(12)"],"pubmed_abstract":["Multidrug-resistant bacterial infections have become a global threat. We recently disclosed that the known IKK-β inhibitor IMD-0354 and subsequent analogues abrogate colistin resistance in several Gram-negative strains. Herein, we report the activity of a second-generation library of IMD-0354 analogues incorporating a benzimidazole moiety as an amide isostere. We identified several analogues that show increased colistin potentiation activity against Gram-negative bacteria."],"journal":["ACS infectious diseases"],"pubmed_title":["Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants."],"pmcid":["PMC8958665"],"funding_grant_id":["R01 AI136904","R01 AI104895","RO1AI136904","RO1AI104895","R01 DE022350"],"pubmed_authors":["Li H","Melander RJ","Ernst RK","Smith R","Jania LA","Koller BH","Melander C","Mattingly AE"],"additional_accession":[]},"is_claimable":false,"name":"Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants.","description":"Multidrug-resistant bacterial infections have become a global threat. We recently disclosed that the known IKK-β inhibitor IMD-0354 and subsequent analogues abrogate colistin resistance in several Gram-negative strains. Herein, we report the activity of a second-generation library of IMD-0354 analogues incorporating a benzimidazole moiety as an amide isostere. We identified several analogues that show increased colistin potentiation activity against Gram-negative bacteria.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-05T12:52:53.361Z","creation":"2025-04-05T12:52:53.361Z"},"accession":"S-EPMC8958665","cross_references":{"pubmed":["34752055"],"doi":["10.1021/acsinfecdis.1c00463"]}}