biostudies-literaturevon Stillfried SBundesministerium für Bildung und ForschungBundesministerium für GesundheitRWTH Aachen University83https://www.ebi.ac.uk/biostudies/studies/S-EPMC8958804biostudies-literatureUnknown26(1)<h4>Background</h4>In severe cases, SARS-CoV-2 infection leads to acute respiratory distress syndrome (ARDS), often treated by extracorporeal membrane oxygenation (ECMO). During ECMO therapy, anticoagulation is crucial to prevent device-associated thrombosis and device failure, however, it is associated with bleeding complications. In COVID-19, additional pathologies, such as endotheliitis, may further increase the risk of bleeding complications. To assess the frequency of bleeding events, we analyzed data from the German COVID-19 autopsy registry (DeRegCOVID).<h4>Methods</h4>The electronic registry uses a web-based electronic case report form. In November 2021, the registry included N = 1129 confirmed COVID-19 autopsy cases, with data on 63 ECMO autopsy cases and 1066 non-ECMO autopsy casCritical care (London, England)Intracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report.PMC8958804DEFEAT PANDEMIcs, 01KX2021ZMVI1-2520COR201Meybohm PStrobel PStadelmann CKasajima ASchadler JKuhn PHKnuchel RMajeed RKlein IMSlotta-Huspenina JWittmann MKling EEichhorn PSpring OAepfelbacher MFischer NRosenwald AKrasemann SUmathum VGVogt NLanger DGattenlohner SSchwab CMeinhardt MTheegarten DThomas CKniep IBocker JEdler CBarth PMeinhardt JClaus RMahlke NBulow RDCoras RHorst DKurz FKlingel KStrobl SLohner LLange FWerner MHirschbuhl KRocken CElezkurtaj SPfefferle SWeichert WCrudele GBirngruber CGFranz JGerman Registry of COVID-19 Autopsies (DeRegCOVID), DeRegCOVID Collaborators#Freeborn BBosmuller HKlein AGranai MDelbridge CTholen PJonigk DBraun GWoloszyn JBittmann IWardelmann EMatschke JKroncke TMeinel MMobius DSchmidt JRudelius MFend FStreit SEvert KHaller FDietz ESchirmacher PDomke LMRohrig RSchnepper AWucherpfennig SBaretton GSeidl MGlatzel MWarm VHilsenbeck JSchilling OPablik JSchaller TFathke CHeinemann AStock KFFitzek AIngenwerth MAmann KUBoor PSommer LGobel HBremer JHolotiuk ORoth WOndruschka BButtner AMarkl BDhillon CWickenhauser CLorenzen JManhart JWienstroer JTitze UMetz ISchroder ASFrob DFriemann JHarder AHeppner FLLutgehetmann MRawitzer JGradhand EEsposito IStork LZechel SHartmann LSperhake JPSteinestel KRadbruch HHartmann AHeinrich Fvon Stillfried SSmith KWerlein CNigbur SHansen TAcker TRommele CSipos EWeis JQuaas APuschel KWild PWeirich GCacchi CReuter TBreitbach ASchmid KWfalseIntracranial hemorrhage in COVID-19 patients during extracorporeal membrane oxygenation for acute respiratory failure: a nationwide register study report.<h4>Background</h4>In severe cases, SARS-CoV-2 infection leads to acute respiratory distress syndrome (ARDS), often treated by extracorporeal membrane oxygenation (ECMO). During ECMO therapy, anticoagulation is crucial to prevent device-associated thrombosis and device failure, however, it is associated with bleeding complications. In COVID-19, additional pathologies, such as endotheliitis, may further increase the risk of bleeding complications. To assess the frequency of bleeding events, we analyzed data from the German COVID-19 autopsy registry (DeRegCOVID).<h4>Methods</h4>The electronic registry uses a web-based electronic case report form. In November 2021, the registry included N = 1129 confirmed COVID-19 autopsy cases, with data on 63 ECMO autopsy cases and 1066 non-ECMO autopsy cas2022-01-01T00:00:00Z2022 Mar2025-05-29T22:15:00.819Z2024-11-09T10:36:23.68ZS-EPMC89588043534631410.1186/s13054-022-03945-x