{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang C"],"funding":["National Institute of Neurological Disorders and Stroke","NINDS NIH HHS","University of Denver"],"pagination":["1838-1849"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8958855"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["157(6)"],"pubmed_abstract":["Zinc has been suggested to act as an intracellular signaling molecule due to its regulatory effects on numerous protein targets including enzymes, transcription factors, ion channels, neurotrophic factors, and postsynaptic scaffolding proteins. However, intracellular zinc concentration is tightly maintained at steady levels under natural physiological conditions. Dynamic changes in intracellular zinc concentration have only been detected in certain types of cells that are exposed to pathologic stimuli or upon receptor ligand binding. Unlike calcium, the ubiquitous signaling metal ion that can oscillate periodically and spontaneously in various cells, spontaneous zinc oscillations have never been reported. In this work, we made the novel observation that the developing neurons generated spo"],"journal":["Journal of neurochemistry"],"pubmed_title":["Spontaneous, synchronous zinc spikes oscillate with neural excitability and calcium spikes in primary hippocampal neuron culture."],"pmcid":["PMC8958855"],"funding_grant_id":["R01 NS110590","R01NS110590"],"pubmed_authors":["Maslar D","Qin Y","Zhang C","LeJeune KD","Minckley TF"],"additional_accession":[]},"is_claimable":false,"name":"Spontaneous, synchronous zinc spikes oscillate with neural excitability and calcium spikes in primary hippocampal neuron culture.","description":"Zinc has been suggested to act as an intracellular signaling molecule due to its regulatory effects on numerous protein targets including enzymes, transcription factors, ion channels, neurotrophic factors, and postsynaptic scaffolding proteins. However, intracellular zinc concentration is tightly maintained at steady levels under natural physiological conditions. Dynamic changes in intracellular zinc concentration have only been detected in certain types of cells that are exposed to pathologic stimuli or upon receptor ligand binding. Unlike calcium, the ubiquitous signaling metal ion that can oscillate periodically and spontaneously in various cells, spontaneous zinc oscillations have never been reported. In this work, we made the novel observation that the developing neurons generated spo","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-05T00:27:30.983Z","creation":"2025-04-05T00:27:30.983Z"},"accession":"S-EPMC8958855","cross_references":{"pubmed":["33638177"],"doi":["10.1111/jnc.15334"]}}