biostudies-literatureUnknown8(2)Hu L<h4>Background</h4>Copy number variation (CNV) has become an essential part of genetic structural variation. Coiled-coil domain containing 39 (CCDC39) is a gene that related to the growth and development of organs and tissues. It is identified that it has a CNV region by animal genome resequencing.<h4>Objective</h4>In this study, we detected the phenotypic traits and different distributions of CCDC39 gene copy numbers in five Chinese cattle breeds (Qinchuan (QC) cattle, Yunling (YL) cattle, Xianan (XN) cattle, Pinan (PN) cattle and Jiaxian (JX) cattle).<h4>Methods</h4>Five hundred and six cattle were randomly selected for CNV distribution detection. Blood samples were taken and genomic DNA was extracted. Different tissues were obtained from adult (n = 3) XN cattle, including heart, liver, Veterinary medicine and science917-924https://www.ebi.ac.uk/biostudies/studies/S-EPMC8959325biostudies-literatureCopy number variation of the CCDC39 gene is associated with growth traits in Chinese cattle.PMC8959325Ru BPeng WShi QWang EChen FYu JHuang RLei CLiu XLi ZHuang YZhang ZYang PHu LChai YfalseCopy number variation of the CCDC39 gene is associated with growth traits in Chinese cattle.<h4>Background</h4>Copy number variation (CNV) has become an essential part of genetic structural variation. Coiled-coil domain containing 39 (CCDC39) is a gene that related to the growth and development of organs and tissues. It is identified that it has a CNV region by animal genome resequencing.<h4>Objective</h4>In this study, we detected the phenotypic traits and different distributions of CCDC39 gene copy numbers in five Chinese cattle breeds (Qinchuan (QC) cattle, Yunling (YL) cattle, Xianan (XN) cattle, Pinan (PN) cattle and Jiaxian (JX) cattle).<h4>Methods</h4>Five hundred and six cattle were randomly selected for CNV distribution detection. Blood samples were taken and genomic DNA was extracted. Different tissues were obtained from adult (n = 3) XN cattle, including heart, liver, 2022-01-01T00:00:00Z2022 Mar2025-04-25T23:01:49.112Z2025-04-06T09:12:57.936ZS-EPMC89593253523395910.1002/vms3.712