{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Karanasos A"],"pubmed_abstract":["<h4>Background</h4>Left atrial (LA) function is linked to atrial fibrillation (AF) pathogenesis. AF catheter ablation decreases disease burden with potentially favorable effects on cardiac function. Atrial volume-pressure loops can optimally assess the LA function.<h4>Objective</h4>To investigate changes in LA function by volume-pressure loops after paroxysmal AF ablation and explored potential differences between the radiofrequency and cryoballoon ablation.<h4>Methods</h4>We analyzed 44 patients undergoing paroxysmal AF ablation from 2 centers, 22 treated with radiofrequency and 22 with cryoablation. Pre- and post-procedure, all patients underwent a real-time three-dimensional transthoracic ECG to evaluate LA volume, while simultaneously recording LA pressure following transseptal puncture. Volume-pressure loops pre- and post-procedure were created by paired data. Areas of A-loop (LA booster pump function) and V-loop (LA reservoir function), and the stiffness constant determining the slope of the exponential curve during LA filling were calculated.<h4>Results</h4>Average LA pressure, A-wave amplitude, and V-wave amplitude were increased post-procedurally (<i>p</i> < 0.001). Overall, A-loop area decreased (<i>p</i> = 0.001) and V-loop area tended to increase (<i>p</i> = 0.07). The change in both A-loop and V-loop areas was similar between radiofrequency- and cryoballoon-treated patients (<i>p</i> = 0.18 and <i>p</i> = 0.52, respectively). However, compared with cryoballoon-treated patients, radiofrequency-treated patients had higher increase in the stiffness constant (<i>b</i> = 0.059; 95% CI: 0.022-0.096; <i>p</i> = 0.006).<h4>Conclusion</h4>AF catheter ablation by the radiofrequency or cryoballoon is associated with the decrease of the booster pump function and increase of the reservoir function. Moreover, there is a post-procedural increase of LA pressure which is associated with an acute increase in LA stiffness in radiofrequency ablation, but not in cryoablation."],"journal":["Frontiers in cardiovascular medicine"],"pagination":["830055"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8959489"],"repository":["biostudies-literature"],"pubmed_title":["Left Atrial Function Post Radiofrequency and Cryoballoon Ablation Assessed by Volume-Pressure Loops."],"pmcid":["PMC8959489"],"pubmed_authors":["Tsiachris D","Karmpalioti M","Kordalis A","Karagiannis S","Toutouzas KP","Gatzoulis K","Tyrovolas K","Prappa E","Efremidis M","Tousoulis D","Aggeli C","Tsioufis C","Karanasos A"],"additional_accession":[]},"is_claimable":false,"name":"Left Atrial Function Post Radiofrequency and Cryoballoon Ablation Assessed by Volume-Pressure Loops.","description":"<h4>Background</h4>Left atrial (LA) function is linked to atrial fibrillation (AF) pathogenesis. AF catheter ablation decreases disease burden with potentially favorable effects on cardiac function. Atrial volume-pressure loops can optimally assess the LA function.<h4>Objective</h4>To investigate changes in LA function by volume-pressure loops after paroxysmal AF ablation and explored potential differences between the radiofrequency and cryoballoon ablation.<h4>Methods</h4>We analyzed 44 patients undergoing paroxysmal AF ablation from 2 centers, 22 treated with radiofrequency and 22 with cryoablation. Pre- and post-procedure, all patients underwent a real-time three-dimensional transthoracic ECG to evaluate LA volume, while simultaneously recording LA pressure following transseptal puncture. Volume-pressure loops pre- and post-procedure were created by paired data. Areas of A-loop (LA booster pump function) and V-loop (LA reservoir function), and the stiffness constant determining the slope of the exponential curve during LA filling were calculated.<h4>Results</h4>Average LA pressure, A-wave amplitude, and V-wave amplitude were increased post-procedurally (<i>p</i> < 0.001). Overall, A-loop area decreased (<i>p</i> = 0.001) and V-loop area tended to increase (<i>p</i> = 0.07). The change in both A-loop and V-loop areas was similar between radiofrequency- and cryoballoon-treated patients (<i>p</i> = 0.18 and <i>p</i> = 0.52, respectively). However, compared with cryoballoon-treated patients, radiofrequency-treated patients had higher increase in the stiffness constant (<i>b</i> = 0.059; 95% CI: 0.022-0.096; <i>p</i> = 0.006).<h4>Conclusion</h4>AF catheter ablation by the radiofrequency or cryoballoon is associated with the decrease of the booster pump function and increase of the reservoir function. Moreover, there is a post-procedural increase of LA pressure which is associated with an acute increase in LA stiffness in radiofrequency ablation, but not in cryoablation.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T00:41:36.784Z","creation":"2025-04-07T11:45:04.936Z"},"accession":"S-EPMC8959489","cross_references":{"pubmed":["35355975"],"doi":["10.3389/fcvm.2022.830055"]}}