biostudies-literatureUnknown9Karanasos A<h4>Background</h4>Left atrial (LA) function is linked to atrial fibrillation (AF) pathogenesis. AF catheter ablation decreases disease burden with potentially favorable effects on cardiac function. Atrial volume-pressure loops can optimally assess the LA function.<h4>Objective</h4>To investigate changes in LA function by volume-pressure loops after paroxysmal AF ablation and explored potential differences between the radiofrequency and cryoballoon ablation.<h4>Methods</h4>We analyzed 44 patients undergoing paroxysmal AF ablation from 2 centers, 22 treated with radiofrequency and 22 with cryoablation. Pre- and post-procedure, all patients underwent a real-time three-dimensional transthoracic ECG to evaluate LA volume, while simultaneously recording LA pressure following transseptal puncture. Volume-pressure loops pre- and post-procedure were created by paired data. Areas of A-loop (LA booster pump function) and V-loop (LA reservoir function), and the stiffness constant determining the slope of the exponential curve during LA filling were calculated.<h4>Results</h4>Average LA pressure, A-wave amplitude, and V-wave amplitude were increased post-procedurally (<i>p</i> < 0.001). Overall, A-loop area decreased (<i>p</i> = 0.001) and V-loop area tended to increase (<i>p</i> = 0.07). The change in both A-loop and V-loop areas was similar between radiofrequency- and cryoballoon-treated patients (<i>p</i> = 0.18 and <i>p</i> = 0.52, respectively). However, compared with cryoballoon-treated patients, radiofrequency-treated patients had higher increase in the stiffness constant (<i>b</i> = 0.059; 95% CI: 0.022-0.096; <i>p</i> = 0.006).<h4>Conclusion</h4>AF catheter ablation by the radiofrequency or cryoballoon is associated with the decrease of the booster pump function and increase of the reservoir function. Moreover, there is a post-procedural increase of LA pressure which is associated with an acute increase in LA stiffness in radiofrequency ablation, but not in cryoablation.Frontiers in cardiovascular medicine830055https://www.ebi.ac.uk/biostudies/studies/S-EPMC8959489biostudies-literatureLeft Atrial Function Post Radiofrequency and Cryoballoon Ablation Assessed by Volume-Pressure Loops.PMC8959489Tsiachris DKarmpalioti MKordalis AKaragiannis SToutouzas KPGatzoulis KTyrovolas KPrappa EEfremidis MTousoulis DAggeli CTsioufis CKaranasos AfalseLeft Atrial Function Post Radiofrequency and Cryoballoon Ablation Assessed by Volume-Pressure Loops.<h4>Background</h4>Left atrial (LA) function is linked to atrial fibrillation (AF) pathogenesis. AF catheter ablation decreases disease burden with potentially favorable effects on cardiac function. Atrial volume-pressure loops can optimally assess the LA function.<h4>Objective</h4>To investigate changes in LA function by volume-pressure loops after paroxysmal AF ablation and explored potential differences between the radiofrequency and cryoballoon ablation.<h4>Methods</h4>We analyzed 44 patients undergoing paroxysmal AF ablation from 2 centers, 22 treated with radiofrequency and 22 with cryoablation. Pre- and post-procedure, all patients underwent a real-time three-dimensional transthoracic ECG to evaluate LA volume, while simultaneously recording LA pressure following transseptal puncture. Volume-pressure loops pre- and post-procedure were created by paired data. Areas of A-loop (LA booster pump function) and V-loop (LA reservoir function), and the stiffness constant determining the slope of the exponential curve during LA filling were calculated.<h4>Results</h4>Average LA pressure, A-wave amplitude, and V-wave amplitude were increased post-procedurally (<i>p</i> < 0.001). Overall, A-loop area decreased (<i>p</i> = 0.001) and V-loop area tended to increase (<i>p</i> = 0.07). The change in both A-loop and V-loop areas was similar between radiofrequency- and cryoballoon-treated patients (<i>p</i> = 0.18 and <i>p</i> = 0.52, respectively). However, compared with cryoballoon-treated patients, radiofrequency-treated patients had higher increase in the stiffness constant (<i>b</i> = 0.059; 95% CI: 0.022-0.096; <i>p</i> = 0.006).<h4>Conclusion</h4>AF catheter ablation by the radiofrequency or cryoballoon is associated with the decrease of the booster pump function and increase of the reservoir function. Moreover, there is a post-procedural increase of LA pressure which is associated with an acute increase in LA stiffness in radiofrequency ablation, but not in cryoablation.2022-01-01T00:00:00Z20222025-04-19T00:41:36.784Z2025-04-07T11:45:04.936ZS-EPMC89594893535597510.3389/fcvm.2022.830055