{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Qi S"],"pubmed_abstract":["Liver ischemia/reperfusion (I/R) injury is a primary complication in major liver surgery. Our previous study about proteome profiling has revealed that the PPAR signaling cascade was significantly upregulated during liver ischemia/reperfusion. To elucidate the potential mechanisms of PPAR<i>α</i> involved in I/R injury, we used oleoylethanolamide (OEA), the peroxisome proliferator-activated receptor alpha (PPAR<i>α</i>) agonist, in this study. We demonstrated a protective role of OEA on liver I/R injury by using a mouse model of partial warm ischemia-reperfusion and hypoxia-reoxygenation model of hepatocytes. These effects were caused by ameliorating liver damage, decreasing the level of serum ALT and AST, and reducing the apoptosis of hepatocytes. Furthermore, a mechanistic study revealed"],"journal":["PPAR research"],"pagination":["2212996"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8960015"],"repository":["biostudies-literature"],"pubmed_title":["Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis."],"pmcid":["PMC8960015"],"pubmed_authors":["Zhan M","Yan Q","Chen L","Du J","Liu D","Qi S","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis.","description":"Liver ischemia/reperfusion (I/R) injury is a primary complication in major liver surgery. Our previous study about proteome profiling has revealed that the PPAR signaling cascade was significantly upregulated during liver ischemia/reperfusion. To elucidate the potential mechanisms of PPAR<i>α</i> involved in I/R injury, we used oleoylethanolamide (OEA), the peroxisome proliferator-activated receptor alpha (PPAR<i>α</i>) agonist, in this study. We demonstrated a protective role of OEA on liver I/R injury by using a mouse model of partial warm ischemia-reperfusion and hypoxia-reoxygenation model of hepatocytes. These effects were caused by ameliorating liver damage, decreasing the level of serum ALT and AST, and reducing the apoptosis of hepatocytes. Furthermore, a mechanistic study revealed","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T20:13:07.549Z","creation":"2025-04-19T20:13:07.549Z"},"accession":"S-EPMC8960015","cross_references":{"pubmed":["35356086"],"doi":["10.1155/2022/2212996"]}}