{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ai LY"],"funding":["Beijing Municipal Natural Science Foundation","National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["844555"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8960627"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["Little has been known about the role of long non-coding RNA (lncRNA) involves in change of aged meniscus. Microarray analyses were performed to identify lncRNAs and mRNAs expression profiles of meniscus in young and aging adults and apple bioinformatics methods to analyse their potential roles. The differentially expressed (DE) lncRNAs and mRNAs were confirmed by qRT-PCR. A total of 1608 DE lncRNAs and 1809 DE mRNAs were identified. Functional and pathway enrichment analyses of all DE mRNAs showed that DE mRNAs were mainly involved in the TGF-beta, Wnt, Hippo, PI3K-Akt signaling pathway. The expressions of TNFRSF11B and BMP2 were significantly upregulated in aging group. LASSO logistic regression analysis of the DE lncRNAs revealed four lncRNAs (AC124312.5, HCG11, POC1B-AS1, and AP001011.1"],"journal":["Frontiers in cell and developmental biology"],"pubmed_title":["Integrated Analysis of lncRNA and mRNA Expression Profiles Indicates Age-Related Changes in Meniscus."],"pmcid":["PMC8960627"],"funding_grant_id":["编号2019YFB1706905","7212132","82072428"],"pubmed_authors":["Chen YR","Ai LY","Zhang JY","Xia PY","Jiang D","Du MZ"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Analysis of lncRNA and mRNA Expression Profiles Indicates Age-Related Changes in Meniscus.","description":"Little has been known about the role of long non-coding RNA (lncRNA) involves in change of aged meniscus. Microarray analyses were performed to identify lncRNAs and mRNAs expression profiles of meniscus in young and aging adults and apple bioinformatics methods to analyse their potential roles. The differentially expressed (DE) lncRNAs and mRNAs were confirmed by qRT-PCR. A total of 1608 DE lncRNAs and 1809 DE mRNAs were identified. Functional and pathway enrichment analyses of all DE mRNAs showed that DE mRNAs were mainly involved in the TGF-beta, Wnt, Hippo, PI3K-Akt signaling pathway. The expressions of TNFRSF11B and BMP2 were significantly upregulated in aging group. LASSO logistic regression analysis of the DE lncRNAs revealed four lncRNAs (AC124312.5, HCG11, POC1B-AS1, and AP001011.1","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T17:44:50.765Z","creation":"2025-02-19T01:55:11.949Z"},"accession":"S-EPMC8960627","cross_references":{"pubmed":["35359458"],"doi":["10.3389/fcell.2022.844555"]}}