biostudies-literatureUnknown12Qin XP<h4>Background</h4>This study determined the predictive value of CRMP4 promoter methylation in prostate tissues collected by core needle biopsies for a postoperative upgrade of Gleason Score (GS) to ≥8 in patients with low-risk PCa.<h4>Method</h4>A retrospective analysis of the clinical data was conducted from 631 patients diagnosed with low-risk PCa by core needle biopsy at multiple centers and then underwent Radical Prostatectomy (RP) from 2014-2019. Specimens were collected by core needle biopsy to detect CRMP4 promoter methylation. The pathologic factors correlated with the postoperative GS upgrade to ≥8 were analyzed by logistic regression. The cut-off value for CRMP4 promoter methylation in the prostate tissues collected by core needle biopsy was estimated from the ROC curve in patieFrontiers in oncology840950https://www.ebi.ac.uk/biostudies/studies/S-EPMC8960729biostudies-literatureCRMP4 CpG Hypermethylation Predicts Upgrading to Gleason Score ≥ 8 in Prostate Cancer.PMC8960729Zhuo YMLiu KLiu JMYang CHLiu WPWang JLi YHQin XPXu YSQu LJQian HJYi XLLu QJChen JFLai CYChen ZRen SCChen XGao XZhou JPan YHfalseCRMP4 CpG Hypermethylation Predicts Upgrading to Gleason Score ≥ 8 in Prostate Cancer.<h4>Background</h4>This study determined the predictive value of CRMP4 promoter methylation in prostate tissues collected by core needle biopsies for a postoperative upgrade of Gleason Score (GS) to ≥8 in patients with low-risk PCa.<h4>Method</h4>A retrospective analysis of the clinical data was conducted from 631 patients diagnosed with low-risk PCa by core needle biopsy at multiple centers and then underwent Radical Prostatectomy (RP) from 2014-2019. Specimens were collected by core needle biopsy to detect CRMP4 promoter methylation. The pathologic factors correlated with the postoperative GS upgrade to ≥8 were analyzed by logistic regression. The cut-off value for CRMP4 promoter methylation in the prostate tissues collected by core needle biopsy was estimated from the ROC curve in patie2022-01-01T00:00:00Z20222025-04-19T12:54:36.695Z2025-04-19T12:54:36.695ZS-EPMC89607293535936910.3389/fonc.2022.840950