biostudies-literatureJiang NNational Natural Science Foundation of ChinaNational Science and Technology Major Project823831https://www.ebi.ac.uk/biostudies/studies/S-EPMC8960857biostudies-literatureUnknown12Mitochondria-related metabolic reprogramming plays a major role in the occurrence, development, drug resistance, and recurrence of acute myeloid leukemia (AML). However, the roles of mitochondria-related genes (MRGs) in the prognosis and immune microenvironment for AML patients remain largely unknown. In this study, by least absolute shrinkage and selection operator (LASSO) Cox regression analysis, 4 MRGs' (HPDL, CPT1A, IDH3A, and ETFB) signature was established that demonstrated good robustness in TARGET AML datasets. The univariate and multivariate Cox regression analyses both demonstrated that the MRG signature was a robust independent prognostic factor in overall survival prediction with high accuracy for AML patients. Based on the risk score calculated by the signature, samples were dFrontiers in oncologyIdentification of a Mitochondria-Related Gene Signature to Predict the Prognosis in AML.PMC896085781774013Wan SLi HWu JChen QLiu JZhang XJiang NKantawong FZhou JLu BfalseIdentification of a Mitochondria-Related Gene Signature to Predict the Prognosis in AML.Mitochondria-related metabolic reprogramming plays a major role in the occurrence, development, drug resistance, and recurrence of acute myeloid leukemia (AML). However, the roles of mitochondria-related genes (MRGs) in the prognosis and immune microenvironment for AML patients remain largely unknown. In this study, by least absolute shrinkage and selection operator (LASSO) Cox regression analysis, 4 MRGs' (HPDL, CPT1A, IDH3A, and ETFB) signature was established that demonstrated good robustness in TARGET AML datasets. The univariate and multivariate Cox regression analyses both demonstrated that the MRG signature was a robust independent prognostic factor in overall survival prediction with high accuracy for AML patients. Based on the risk score calculated by the signature, samples were d2022-01-01T00:00:00Z20222025-04-04T19:10:46.253Z2025-04-04T19:10:46.253ZS-EPMC89608573535939410.3389/fonc.2022.823831