{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Palma-Chavez J"],"funding":["U.S. Food and Drug Administration","National Institutes of Health","NIH HHS","National Science Foundation"],"pagination":["100348"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8960980"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26"],"pubmed_abstract":["Standardized phantoms and test methods are needed to accelerate clinical translation of emerging photoacoustic imaging (PAI) devices. Evaluating object detectability in PAI is challenging due to variations in target morphology and artifacts including boundary buildup. Here we introduce breast fat and parenchyma tissue-mimicking materials based on emulsions of silicone oil and ethylene glycol in polyacrylamide hydrogel. 3D-printed molds were used to fabricate solid target inclusions that produced more filled-in appearance than traditional PAI phantoms. Phantoms were used to assess understudied image quality characteristics (IQCs) of three PAI systems. Object detectability was characterized vs. target diameter, absorption coefficient, and depth. Boundary buildup was quantified by target core/boundary ratio, which was higher in transducers with lower center frequency. Target diameter measurement accuracy was also size-dependent and improved with increasing transducer frequency. These phantoms enable evaluation of multiple key IQCs and may support development of comprehensive standardized test methods for PAI devices."],"journal":["Photoacoustics"],"pubmed_title":["Photoacoustic imaging phantoms for assessment of object detectability and boundary buildup artifacts."],"pmcid":["PMC8960980"],"funding_grant_id":["S10 OD023555","1842387","1937674","S10 OD021821"],"pubmed_authors":["Jokerst JV","Vogt WC","Wear KA","Palma-Chavez J","Mantri Y"],"additional_accession":[]},"is_claimable":false,"name":"Photoacoustic imaging phantoms for assessment of object detectability and boundary buildup artifacts.","description":"Standardized phantoms and test methods are needed to accelerate clinical translation of emerging photoacoustic imaging (PAI) devices. Evaluating object detectability in PAI is challenging due to variations in target morphology and artifacts including boundary buildup. Here we introduce breast fat and parenchyma tissue-mimicking materials based on emulsions of silicone oil and ethylene glycol in polyacrylamide hydrogel. 3D-printed molds were used to fabricate solid target inclusions that produced more filled-in appearance than traditional PAI phantoms. Phantoms were used to assess understudied image quality characteristics (IQCs) of three PAI systems. Object detectability was characterized vs. target diameter, absorption coefficient, and depth. Boundary buildup was quantified by target core/boundary ratio, which was higher in transducers with lower center frequency. Target diameter measurement accuracy was also size-dependent and improved with increasing transducer frequency. These phantoms enable evaluation of multiple key IQCs and may support development of comprehensive standardized test methods for PAI devices.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-26T15:14:21.623Z","creation":"2025-04-06T14:52:07.806Z"},"accession":"S-EPMC8960980","cross_references":{"pubmed":["35360521"],"doi":["10.1016/j.pacs.2022.100348"]}}