{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(5)"],"submitter":["Costentin C"],"pubmed_abstract":["<h4>Background & aims</h4>Patients with hepatocellular carcinoma (HCC) are selected for liver transplantation (LT) based on pre-LT imaging ± alpha-foetoprotein (AFP) level, but discrepancies between pre-LT tumour assessment and explant are frequent. Our aim was to design an explant-based recurrence risk reassessment score to refine prediction of recurrence after LT and provide a framework to guide post-LT management.<h4>Methods</h4>Adult patients who underwent transplantation between 2000 and 2018 for HCC in 47 centres were included. A prediction model for recurrence was developed using competing-risk regression analysis in a European training cohort (TC; n = 1,359) and tested in a Latin American validation cohort (VC; n=1,085).<h4>Results</h4>In the TC, 76.4% of patients with HCC met the "],"journal":["JHEP reports : innovation in hepatology"],"pagination":["100445"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8961219"],"repository":["biostudies-literature"],"pubmed_title":["R3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation."],"pmcid":["PMC8961219"],"pubmed_authors":["Burra P","Muscari F","Dharancy S","Valerio L","Christophe M","Gambato M","Cillo U","Parente Garcia JH","Magini G","Olivier D","Pellicelli A","Fatima Boin IS","Boin IF","Pinelli D","Maraschio M","Baccaro C","Vilatoba M","Boudjema K","Deledinghen V","Altieri M","Paul LJ","Francoz C","Quinones E","Eduard C","Di Benedetto F","Silva M","Mattera J","Colasanti M","Jonas S","Anders M","Fagiuoli S","Colledan M","Pageaux GP","Gugenheim J","Radenne S","Dirk Y","Conti F","Houssel-Debry P","Vitale A","Cristina de Ataide E","Vennarecci G","Giannelli V","Dibenedetto F","Chagas A","Decaens T","Ettorre GM","French-Italian-Belgium and Latin American collaborative group for HCC and liver transplantation","Menendez RC","Podesta LG","Woehl ML","Costentin C","Costa P","Van Vlierberghe H","Duque SH","Zerega A","Magistri P","Samuele I","Roberto T","Duvoux C","Notarpaolo A","Carrilho F","Dumortier J","Chiche L","D'Ambrosio C","Rubinstein F","Menendez J","Bernard PH","Varon A","Jeroen D","Salame E","Hardwigsen J","Barbier L","Laurent A","Zapata R","Gadano A","Cherqui D","Peter M","Abergel A","McCormack L","Poniachik J","Vanlemmens C","Munoz L","Hilleret MN","Degroote H","Miglioresi L","Chris V","Bachellier P","Durand F","Jean D","Soza A","Pinero F","Scatton O","Jacques P","Lai Q","Arufe D","Marciano S","Machaca MP"],"additional_accession":[]},"is_claimable":false,"name":"R3-AFP score is a new composite tool to refine prediction of hepatocellular carcinoma recurrence after liver transplantation.","description":"<h4>Background & aims</h4>Patients with hepatocellular carcinoma (HCC) are selected for liver transplantation (LT) based on pre-LT imaging ± alpha-foetoprotein (AFP) level, but discrepancies between pre-LT tumour assessment and explant are frequent. Our aim was to design an explant-based recurrence risk reassessment score to refine prediction of recurrence after LT and provide a framework to guide post-LT management.<h4>Methods</h4>Adult patients who underwent transplantation between 2000 and 2018 for HCC in 47 centres were included. A prediction model for recurrence was developed using competing-risk regression analysis in a European training cohort (TC; n = 1,359) and tested in a Latin American validation cohort (VC; n=1,085).<h4>Results</h4>In the TC, 76.4% of patients with HCC met the ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-30T15:03:20.906Z","creation":"2025-04-04T23:03:09.641Z"},"accession":"S-EPMC8961219","cross_references":{"pubmed":["35360522"],"doi":["10.1016/j.jhepr.2022.100445"]}}